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Blood, 1 December 2007, Vol. 110, No. 12, pp. 4120-4122. Prepublished online as a Blood First Edition Paper on August 27, 2007; DOI 10.1182/blood-2007-05-089805. This Article Full Text Full Text (PDF) Supplemental Methods All Versions of this Article: blood-2007-05-089805v1 110/12/4120    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lopes, J. V. Articles by Dingli, D. Search for Related Content PubMed PubMed Citation Articles by Lopes, J. V. Articles by Dingli, D. Related Collections Hematopoiesis and Stem Cells Stem Cells in Hematology Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  STEM CELLS IN HEMATOLOGY Brief Report Acquired hematopoietic stem-cell disorders and mammalian size Joao V. Lopes1, Jorge M. Pacheco1,2, and David Dingli2,3 1 Centro de Física Teórica e Computacional and Departamento de Física da Faculdade de Ciências, Universidade Lisboa, Lisboa, Portugal; 2 Program for Evolutionary Dynamics, Harvard University, Cambridge, MA; and 3 Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN Hematopoietic stem cells (HSCs) can both self renew and differentiate into precursors of all types of blood cells. HSCs are divided into an active pool and a quiescent reserve. Cells selected for the active pool contribute to hematopoiesis for many years. Mutations in HSCs can lead to neoplasms such as chronic myeloid leukemia, although the risk of neoplastic HSC disorders varies across mammals. We use allometric scaling relations combined with mutation-selection evolutionary dynamics to determine which mammalian species is most resistant to HSC disorders. We find that the advantage of large mammals at escaping the selective pressure of cancer cells is insufficient to overcome the increased risk of acquiring mutations. Hence, mutation dominates, which favors smaller stem-cell pools and, consequently, smaller mammals, since these minimize the development of mutations in the active stem-cell pool. Consequently, the smaller the active stem-cell pools, the better. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020