SEARCH:   Advanced

Blood, 15 December 2007, Vol. 110, No. 13, pp. 4303-4311. Prepublished online as a Blood First Edition Paper on September 10, 2007; DOI 10.1182/blood-2007-04-087486. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-04-087486v1 110/13/4303    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lantner, F. Articles by Shachar, I. Search for Related Content PubMed PubMed Citation Articles by Lantner, F. Articles by Shachar, I. Related Collections Immunobiology Apoptosis Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY CD74 induces TAp63 expression leading to B-cell survival Frida Lantner1, Diana Starlets1, Yael Gore1, Liat Flaishon2, Ayala Yamit-Hezi3, Rivka Dikstein3, Lin Leng4, Richard Bucala4, Yossy Machluf2, Moshe Oren2, and Idit Shachar1 Departments of1 Immunology 2 Molecular Cell Biology, and 3 Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel; and 4 Department of Medicine, Yale University School of Medicine, New Haven, CT Most mature follicular B cells circulate within the periphery in a quiescent state, without actively contributing to an acute immune response. Lasting B-cell persistence in the periphery is dependent on survival signals that are transduced by cell surface receptors. We recently demonstrated that cell surface CD74 controls mature B-cell survival. Stimulation of cell surface CD74 leads to NF-B activation, which enables entry of the stimulated B cells into the S phase, induction of DNA synthesis, and cell division, and augments the expression of survival genes. In the present study, we investigated CD74 target genes to determine the identities of the molecules whose expression is modulated by CD74, thereby regulating B-cell survival. We report that CD74 activates the p65 member of the NF-B family, which in turn up-regulates the expression of p53-related TAp63 proteins. TAp63 then binds and transactivates the Bcl-2gene and induces the production of Bcl-2 protein, thereby providing the cells with increased survival capacity. Thus, the CD74/NF-B/TAp63 axis defines a novel antiapoptotic pathway in mature B cells, resulting in the shaping of both the B-cell repertoire and the immune response. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Suenaga, T. Ozaki, Y. Tanaka, Y. Bu, T. Kamijo, T. Tokuhisa, A. Nakagawara, and T.-a. Tamura TATA-binding Protein (TBP)-like Protein Is Engaged in Etoposide-induced Apoptosis through Transcriptional Activation of Human TAp63 Gene J. Biol. Chem., December 18, 2009; 284(51): 35433 - 35440. [Abstract] [Full Text] [PDF] Z. Berkova, S. Wang, J. F. Wise, H. Maeng, Y. Ji, and F. Samaniego Mechanism of Fas Signaling Regulation by Human Herpesvirus 8 K1 Oncoprotein J Natl Cancer Inst, March 18, 2009; 101(6): 399 - 411. [Abstract] [Full Text] [PDF]

	Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020