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Blood, 15 December 2007, Vol. 110, No. 13, pp. 4543-4551. Prepublished online as a Blood First Edition Paper on August 1, 2007; DOI 10.1182/blood-2007-05-092130. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-05-092130v1 110/13/4543    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Komanduri, K. V. Articles by Shpall, E. J. Search for Related Content PubMed PubMed Citation Articles by Komanduri, K. V. Articles by Shpall, E. J. Related Collections Immunobiology Transplantation Free Research Articles Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing Krishna V. Komanduri1, Lisa S. St. John1, Marcos de Lima1, John McMannis1, Steven Rosinski2, Ian McNiece2,3, Susan G. Bryan1, Indreshpal Kaur1, Sean Martin1, Eric D. Wieder1, Laura Worth1, Laurence J. N. Cooper1, Demetrios Petropoulos1, Jeffrey J. Molldrem1, Richard E. Champlin1, and Elizabeth J. Shpall1 1 Department of Stem Cell Transplantation and Cellular Therapy, M. D. Anderson Cancer Center, Houston, TX; 2 Joint MD, PhD Graduate Program, University of Colorado, Denver; and 3 University of Miami Miller School of Medicine, FL Advances in immune assessment, including the development of T-cell receptor excision circle (TREC) assays of thymopoiesis, cytokine-flow cytometry assays of T-cell function, and higher-order phenotyping of T-cell maturation subsets have improved our understanding of T-cell homeostasis. Limited data exist using these methods to characterize immune recovery in adult cord blood (CB) transplant recipients, in whom infection is a leading cause of mortality. We now report the results of a single-center prospective study of T-cell immune recovery after cord blood transplantation (CBT) in a predominantly adult population. Our primary findings include the following: (1) Prolonged T lymphopenia and compensatory expansion of B and natural killer (NK) cells was evident; (2) CB transplant recipients had impaired functional recovery, although we did observe posttransplantation de novo T-cell responses to cytomegalovirus (CMV) in a subset of patients; (3) Thymopoietic failure characterized post-CBT immune reconstitution, in marked contrast to results in other transplant recipients; and (4) Thymopoietic failure was associated with late memory T-cell skewing. Our data suggest that efforts to improve outcomes in adult CB transplant recipients should be aimed at optimizing T-cell immune recovery. Strategies that improve the engraftment of lymphoid precursors, protect the thymus during pretransplant conditioning, and/or augment the recovery of thymopoiesis may improve outcomes after CBT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Immune reconstitution after unrelated cord blood transplants in adults Eliane Gluckman Blood 2007 110: 4136. [Full Text] [PDF] This article has been cited by other articles: T. K. Kim, L. S. St. John, E. D. Wieder, J. Khalili, Q. Ma, and K. V. Komanduri Human Late Memory CD8+ T Cells Have a Distinct Cytokine Signature Characterized by CC Chemokine Production without IL-2 Production J. Immunol., November 15, 2009; 183(10): 6167 - 6174. [Abstract] [Full Text] [PDF] P. J. Hanley, C. R. Y. Cruz, B. Savoldo, A. M. Leen, M. Stanojevic, M. Khalil, W. Decker, J. J. Molldrem, H. Liu, A. P. Gee, et al. Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes Blood, August 27, 2009; 114(9): 1958 - 1967. [Abstract] [Full Text] [PDF] S. J. Opiela, T. Koru-Sengul, and B. Adkins Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants Blood, May 28, 2009; 113(22): 5635 - 5643. [Abstract] [Full Text] [PDF]

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