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Blood, 15 December 2007, Vol. 110, No. 13, pp. 4576-4583. Prepublished online as a Blood First Edition Paper on September 4, 2007; DOI 10.1182/blood-2007-06-097386. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: blood-2007-06-097386v1 110/13/4576    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lee, S. J. Articles by Anasetti, C. Search for Related Content PubMed PubMed Citation Articles by Lee, S. J. Articles by Anasetti, C. Related Collections Transplantation Clinical Trials and Observations Immunobiology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation Stephanie J. Lee1, John Klein2, Michael Haagenson3, Lee Ann Baxter-Lowe4, Dennis L. Confer5, Mary Eapen2, Marcelo Fernandez-Vina6, Neal Flomenberg7, Mary Horowitz2, Carolyn K. Hurley8, Harriet Noreen9, Machteld Oudshoorn10, Effie Petersdorf1, Michelle Setterholm5, Stephen Spellman5, Daniel Weisdorf11, Thomas M. Williams12, and Claudio Anasetti13 1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 2 Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; 3 Center for International Blood and Marrow Transplant Research, Minneapolis, MN; 4 Department of Surgery, University of California, San Francisco; 5 National Marrow Donor Program, Minneapolis, MN; 6 M. D. Anderson Cancer Center, Houston, TX; 7 Thomas Jefferson University Hospital, Philadelphia, PA; 8 Department of Oncology, Georgetown University Medical Center, Washington, DC; 9 Immunology/Histocompatibility Laboratory, University of Minnesota Medical Center, Fairview; 10 Europdonor Foundation, Leiden, the Netherlands; 11 Blood and Marrow Transplantation (BMT) Program, University of Minnesota, Minneapolis; 12 Department of Pathology, University of New Mexico, Albuquerque; and 13 H. Lee Moffitt Cancer Center, Tampa, FL The relative importance of various human leukocyte antigen (HLA) loci and the resolution level at which they are matched has not been fully defined for unrelated donor transplantation. To address this question, National Marrow Donor Program data from 3857 transplantations performed from 1988 to 2003 in the United States were analyzed. Patient-donor pairs were fully typed for HLA-A, -B, -C, -DRB1, -DQB1, -DQA1, -DPB1, and -DPA1 alleles. High-resolution DNA matching for HLA-A, -B, -C, and -DRB1 (8/8 match) was the minimum level of matching associated with the highest survival. A single mismatch detected by low- or high-resolution DNA testing at HLA-A, -B, -C or -DRB1 (7/8 match) was associated with higher mortality (relative risk, 1.25; 95% CI, 1.13-1.38; P < .001) and 1-year survival of 43% compared with 52% for 8/8 matched pairs. Single mismatches at HLA-B or HLA-C appear better tolerated than mismatches at HLA-A or HLA-DRB1. Mismatching at 2 or more loci compounded the risk. Mismatching at HLA-DP or -DQ loci and donor factors other than HLA type were not associated with survival. In multivariate modeling, patient age, race, disease stage, and cytomegalovirus status were as predictive of survival as donor HLA matching. High-resolution DNA matching for HLA-A, -B, -C, and -DRB1 alleles is associated with higher rates of survival. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism Takakazu Kawase, Yasuo Morishima, Keitaro Matsuo, Koichi Kashiwase, Hidetoshi Inoko, Hiroh Saji, Shunichi Kato, Takeo Juji, Yoshihisa Kodera, and Takehiko Sasazuki, for The Japan Marrow Donor Program Blood 2007 110: 2235-2241. [Abstract] [Full Text] [PDF]

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