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Blood, 15 July 2007, Vol. 110, No. 2, pp. 485-489. Prepublished online as a Blood First Edition Paper on April 10, 2007; DOI 10.1182/blood-2007-01-071068. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-01-071068v1 110/2/485    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Passamonti, F. Articles by Lazzarino, M. Search for Related Content PubMed PubMed Citation Articles by Passamonti, F. Articles by Lazzarino, M. Related Collections Oncogenes and Tumor Suppressors Free Research Articles Clinical Trials and Observations Hemostasis, Thrombosis, and Vascular Biology Neoplasia Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Increased risk of pregnancy complications in patients with essential thrombocythemia carrying the JAK2 (617V>F) mutation Francesco Passamonti1, Maria Luigia Randi2, Elisa Rumi1, Ester Pungolino3, Chiara Elena1, Daniela Pietra1, Margherita Scapin2, Luca Arcaini1, Fabiana Tezza2, Remigio Moratti4, Cristiana Pascutto1, Fabrizio Fabris2, Enrica Morra3, Mario Cazzola1, and Mario Lazzarino1 1 Department of Hematology, University of Pavia Medical School, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia; 2 Department of Medical and Surgical Sciences—Chirurgiche, Sezione Medicina Interna (CLOPD), University of Padova Medical School, Padova; 3 Division of Hematology, Ospedale Niguarda Ca' Granda, Milan; 4 Department of Clinical Chemistry, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy Essential thrombocythemia (ET) may occur in women of childbearing age. To investigate the risk of pregnancy complications, we studied 103 pregnancies that occurred in 62 women with ET. The 2-tailed Fisher exact test showed that pregnancy outcome was independent from that of a previous pregnancy. The rate of live birth was 64%, and 51% of pregnancies were uneventful. Maternal complications occurred in 9%, while fetal complications occurred in 40% of pregnancies. The Mantel-Haenszel method showed that fetal loss in women with ET was 3.4-fold higher (95% confidence interval [CI]: 3-3.9; P < .001) than in the general population. Half of the women studied carried the JAK2 (617V>F) mutation, and a multivariate logistic regression model identified this mutation as an independent predictor of pregnancy complications (P = .01). Neither the platelet count nor the leukocyte count was a risk factor. JAK2 (617V>F)–positive patients had an odds ratio of 2.02 (95% CI: 1.1 - 3.8) of developing complications in comparison with JAK2 (617V>F)–negative patients. Aspirin did not prevent complication in JAK2 (617V>F)–positive patients and appeared to worsen outcome in JAK2 (617V>F)–negative patients. A relationship was found between JAK2 (617V>F) and fetal loss (P = .05). This study indicates that patients carrying the JAK2 (617V>F) mutation have higher risk of developing pregnancy complications. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Thrombocytosis, pregnancy, and regression toward mean Jerry L. Spivak Blood 2007 110: 472-473. [Full Text] [PDF] This article has been cited by other articles: E. Antonioli, P. Guglielmelli, G. Poli, C. Bogani, A. Pancrazzi, G. Longo, V. Ponziani, L. Tozzi, L. Pieri, V. Santini, et al. Influence of JAK2V617F allele burden on phenotype in essential thrombocythemia Haematologica, January 1, 2008; 93(1): 41 - 48. [Abstract] [Full Text] [PDF] Gene Mutations and Pregnancy Complications Journal Watch Oncology and Hematology, August 7, 2007; 2007(807): 1 - 1. [Full Text]

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