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Blood, 15 July 2007, Vol. 110, No. 2, pp. 568-577. Prepublished online as a Blood First Edition Paper on March 19, 2007; DOI 10.1182/blood-2006-11-057125. This Article Full Text Full Text (PDF) Supplemental Methods and Figures All Versions of this Article: blood-2006-11-057125v1 110/2/568    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Feger, U. Articles by Wiendl, H. Search for Related Content PubMed PubMed Citation Articles by Feger, U. Articles by Wiendl, H. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation Ute Feger1, Eva Tolosa1, Yu-Hwa Huang2, Anne Waschbisch2, Tilo Biedermann3, Arthur Melms1, and Heinz Wiendl1,2 1 Department of General Neurology, Hertie-Institute for Clinical Brain Research, Eberhard-Karls-University Tuebingen, Tuebingen; 2 Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Wuerzburg, Julius-Maximilians-University Wuerzburg, Wuerzburg; 3 Department of Dermatology, Eberhard-Karls-University Tuebingen, Tuebingen, Germany Regulatory T cells can inhibit harmful immunopathologic responses directed against self and foreign antigens and play a major role in controlling autoimmunity. Here we have identified and characterized a subpopulation of CD4 and CD8 T cells in human peripheral blood expressing the immune tolerizing molecule HLA-G. HLA-G–expressing T cells are hypoproliferative, are CD25- and FOXP3-negative, and exhibit potent suppressive properties that are partially mediated by HLA-G. HLA-G–positive (HLA-Gpos) T cells are found at low percentages among CD4 and CD8 single-positive thymocytes, suggesting a thymic origin. The presence of HLA-Gpos T cells at sites of inflammation such as inflamed skeletal muscle in myositis or the cerebrospinal fluid of patients with acute neuroinflammatory disorders suggests an important function in modulating parenchymal inflammatory responses in vivo. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. D. Carosella, B. Favier, N. Rouas-Freiss, P. Moreau, and J. LeMaoult Beyond the increasing complexity of the immunomodulatory HLA-G molecule Blood, May 15, 2008; 111(10): 4862 - 4870. [Abstract] [Full Text] [PDF] E. Fainardi, R. Rizzo, L. Melchiorri, M. Stignani, M. Castellazzi, C. Tamborino, E. Paolino, M. Tola, E. Granieri, and O. Baricordi CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI evidence of disease activity in patients with relapsing--remitting multiple sclerosis Multiple Sclerosis, May 1, 2008; 14(4): 446 - 454. [Abstract] [PDF] M. Urosevic and R. Dummer Human Leukocyte Antigen-G and Cancer Immunoediting Cancer Res., February 1, 2008; 68(3): 627 - 630. [Abstract] [Full Text] [PDF]

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