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Blood, 15 July 2007, Vol. 110, No. 2, pp. 568-577.
Prepublished online as a Blood First Edition Paper on March 19, 2007; DOI 10.1182/blood-2006-11-057125.
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IMMUNOBIOLOGY
HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation
Ute Feger1,
Eva Tolosa1,
Yu-Hwa Huang2,
Anne Waschbisch2,
Tilo Biedermann3,
Arthur Melms1, and
Heinz Wiendl1,2
1 Department of General Neurology, Hertie-Institute for Clinical Brain Research, Eberhard-Karls-University Tuebingen, Tuebingen;
2 Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Wuerzburg, Julius-Maximilians-University Wuerzburg, Wuerzburg;
3 Department of Dermatology, Eberhard-Karls-University Tuebingen, Tuebingen, Germany
Regulatory T cells can inhibit harmful immunopathologic responses directed against self and foreign antigens and play a major role in controlling autoimmunity. Here we have identified and characterized a subpopulation of CD4 and CD8 T cells in human peripheral blood expressing the immune tolerizing molecule HLA-G. HLA-G–expressing T cells are hypoproliferative, are CD25- and FOXP3-negative, and exhibit potent suppressive properties that are partially mediated by HLA-G. HLA-G–positive (HLA-Gpos) T cells are found at low percentages among CD4 and CD8 single-positive thymocytes, suggesting a thymic origin. The presence of HLA-Gpos T cells at sites of inflammation such as inflamed skeletal muscle in myositis or the cerebrospinal fluid of patients with acute neuroinflammatory disorders suggests an important function in modulating parenchymal inflammatory responses in vivo.
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