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 Blood, 1 August 2007, Vol. 110, No. 3, pp. 799-805.
Prepublished online as a Blood First Edition Paper on April 5, 2007; DOI 10.1182/blood-2006-11-019265.

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REVIEW ARTICLE

Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts

Luke F. Peterson1, Anita Boyapati1, Eun-Young Ahn1, Joseph R. Biggs1, Akiko Joo Okumura1, Miao-Chia Lo1, Ming Yan1, and Dong-Er Zhang1

1 Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA

Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.


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