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Blood, 1 August 2007, Vol. 110, No. 3, pp. 799-805.
Prepublished online as a Blood First Edition Paper on April 5, 2007; DOI 10.1182/blood-2006-11-019265.
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REVIEW ARTICLE
Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts
Luke F. Peterson1,
Anita Boyapati1,
Eun-Young Ahn1,
Joseph R. Biggs1,
Akiko Joo Okumura1,
Miao-Chia Lo1,
Ming Yan1, and
Dong-Er Zhang1
1 Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA
Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.

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