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 Blood, 1 August 2007, Vol. 110, No. 3, pp. 851-859.
Prepublished online as a Blood First Edition Paper on April 5, 2007; DOI 10.1182/blood-2006-05-022087.

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HEMATOPOIESIS

PECAM-1: a multifaceted regulator of megakaryocytopoiesis

Yue Wu1, Thomas Welte1, Michael Michaud1, and Joseph A. Madri1

1 Department of Pathology, Yale University School of Medicine, New Haven, CT

PECAM-1 (CD31) knockout (KO) mice exhibit excessive megakaryocytopoiesis accompanied by increased numbers of megakaryocytes associated with the stromal niche rather than the vascular niche. During earlier stages of megakaryocytopoiesis in KO marrow, an expanded Lin–Sca-1+ c-kit+ hematopoietic stem cell (HSC) population and increased quiescent Lin– progenitor pool were identified. During the later stages of megakaryocytopoiesis, CD31KO megakaryocytes exhibited abnormal adhesion/transmigration behaviors. Lastly, KO animals exhibited excessive splenic extramedullary megakaryocytopoiesis, which likely compensates for the impaired marrow megakaryocytopoiesis, resulting in normal peripheral platelet number. Thus, PECAM-1 modulates megakaryocytopoiesis in a hierarchic manner, functioning as a thermostat to "fine-tune" megakaryocytopoiesis.


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C. Bergom, C. Paddock, C. Gao, T. Holyst, D. K. Newman, and P. J. Newman
An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling
J. Cell Sci., April 15, 2008; 121(8): 1235 - 1242.
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