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Blood, 15 August 2007, Vol. 110, No. 4, pp. 1178-1183. Prepublished online as a Blood First Edition Paper on April 17, 2007; DOI 10.1182/blood-2007-01-066043. This Article Full Text Full Text (PDF) Supplemental Appendix and Tables All Versions of this Article: blood-2007-01-066043v1 110/4/1178    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Galli, M. Articles by Barbui, T. Search for Related Content PubMed PubMed Citation Articles by Galli, M. Articles by Barbui, T. Related Collections Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Clinical significance of different antiphospholipid antibodies in the WAPS (warfarin in the antiphospholipid syndrome) study Monica Galli1, Giovanna Borrelli2, Eva Marie Jacobsen3, Rosa Maria Marfisi2, Guido Finazzi1, Roberto Marchioli2, Finn Wisloff3, Stefana Marziali1, Olivier Morboeuf4, and Tiziano Barbui1 1 Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy; 2 Laboratory of Epidemiology, Istituto Mario Negri Sud, S. Maria Imbaro, Chieti, Italy; 3 Ulleval Hospital, Oslo, Norway; 4 Diagnostica Stago, Asnieres, France To assess the clinical significance of lupus anticoagulants (LAs) and antiphospholipid antibodies (aPLs) toward thrombosis and abortions, we measured them in 112 patients whose samples were available at enrollment in the warfarin in the antiphospholipid syndrome (WAPS) study. Enzyme-linked immunosorbent assay (ELISA) and coagulation test values in the highest and lowest tertiles were compared. When considered separately, IgG antibodies to β2-glycoprotein I (aβ2GPI) and prothrombin (aPT) were associated with anamnestic arterial and venous thrombosis, respectively, and those to annexin AV (aAnAV) with abortions. IgM antibodies to protein S and the lupus ratio of the dilute prothrombin time were associated with prospective thrombosis. No other association for IgM antibodies was seen. LA-positive patients who carried aβ2GPI antibodies were at risk of anamnestic arterial and total thrombosis and aPT antibodies to that of anamnestic venous and total thrombosis. LA-positive patients who carried IgG aβ2GPI and aAnAV antibodies were at risk for both anamnestic abortion and prospective thrombosis. Overall, these data support the inclusion of aβ2GPI antibodies in and suggest the removal of anticardiolipin antibodies from the laboratory criteria of the antiphospholipid syndrome. They also suggest that the measurement of aPT and aAnAV antibodies is useful in some selected situations and that there is little role for IgM antibody detection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Y. Chan, F. Andreotti, and R. C. Becker Hypercoagulable States in Cardiovascular Disease Circulation, November 25, 2008; 118(22): 2286 - 2297. [Full Text] [PDF] M. M Patnaik, K. Wudhikarn, M. M Shroff, A. A Killeen, M. T. Reding, and R. S. Kasthuri Spectrum of Antiphospholipid Antibodies and Associated Thrombotic and Obstetric Events among Patients with Antiphospholipid Syndrome Blood (ASH Annual Meeting Abstracts), November 16, 2008; 112(11): 5343 - 5343. [Abstract] S. M. Nelson and I. A. Greer The potential role of heparin in assisted conception Hum. Reprod. Update, November 1, 2008; 14(6): 623 - 645. [Abstract] [Full Text] [PDF] R Forastiero and M Martinuzzo Prothrombotic mechanisms based on the impairment of fibrinolysis in the antiphospholipid syndrome Lupus, October 1, 2008; 17(10): 872 - 877. [Abstract] [PDF] I Giles, A Lambrianides, and A Rahman Examining the non-linear relationship between monoclonal antiphospholipid antibody sequence, structure and function Lupus, October 1, 2008; 17(10): 895 - 903. [Abstract] [PDF] M. Borrell, I. Tirado, J. Mateo, A. Oliver, A. Santamaria, and J. Fontcuberta IgM anti-protein S antibodies as a risk factor for venous thrombosis Haematologica, July 1, 2008; 93(7): 1115 - 1117. [Full Text] [PDF] A. Membre, D. Wahl, V. Latger-Cannard, J.-P. Max, P. Lacolley, T. Lecompte, and V. Regnault The effect of platelet activation on the hypercoagulability induced by murine monoclonal antiphospholipid antibodies Haematologica, April 1, 2008; 93(4): 566 - 573. [Abstract] [Full Text] [PDF] Diagnosing Antiphospholipid Antibody Syndrome Journal Watch Oncology and Hematology, September 11, 2007; 2007(911): 1 - 1. [Full Text]

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