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Blood, 15 August 2007, Vol. 110, No. 4, pp. 1326-1329. Prepublished online as a Blood First Edition Paper on April 16, 2007; DOI 10.1182/blood-2007-01-066100. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-01-066100v1 110/4/1326    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gandhi, M. K. Articles by Khanna, R. Search for Related Content PubMed PubMed Citation Articles by Gandhi, M. K. Articles by Khanna, R. Related Collections Immunobiology Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief Report Galectin-1 mediated suppression of Epstein-Barr virus–specific T-cell immunity in classic Hodgkin lymphoma Maher K. Gandhi1,3, Guido Moll1, Corey Smith1, Ujjwal Dua1, Eleanore Lambley1, Olivier Ramuz2, Devinder Gill3, Paula Marlton3, John F. Seymour4, and Rajiv Khanna1 1 Australian Centre for Vaccine Development, Tumor Immunology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane; 2 Molecular and Cellular Pathology, School of Medicine, University of Queensland, Brisbane; 3 Department of Haematology, Princess Alexandra Hospital, Brisbane; and 4 Haematology Service, Peter MacCallum Cancer Centre, and University of Melbourne, Melbourne, Australia In Hodgkin lymphoma (HL), the malignant Hodgkin Reed-Sternberg cells interact with the host microenvironment to create an immunosuppressive network that protects the lymphoma from immune attack. These mechanisms are not fully understood. We examined the role of the immunomodulatory protein galectin-1 (Gal-1) on Epstein-Barr virus-specific CD8+ T cell responses in HL. Initial studies indicated Gal-1 expression in all in vitro established Hodgkin Reed-Sternberg cell lines. In situ analysis revealed Gal-1 expression in 26 of 42 classic HL, whereas Gal-1 was uniformly negative in nodular lymphocyte predominant HL. Gal-1hi expression was associated with male gender, older patients, reduced CD8+ T cell infiltration at the tumor site, and most importantly, an impaired latent membrane protein 1 and 2-specific CD8+ T-cell responses. In vitro exposure to recombinant Gal-1 inhibited proliferation and interferon- expression by Epstein-Barr virus-specific T cells. These observations provide an important link between the Gal-1-mediated immunomodulatory networks and loss of antigen-specific T-cell function in classic HL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Poisa-Beiro, S. Dios, H. Ahmed, G. R. Vasta, A. Martinez-Lopez, A. Estepa, J. Alonso-Gutierrez, A. Figueras, and B. Novoa Nodavirus Infection of Sea Bass (Dicentrarchus labrax) Induces Up-Regulation of Galectin-1 Expression with Potential Anti-Inflammatory Activity J. Immunol., November 15, 2009; 183(10): 6600 - 6611. [Abstract] [Full Text] [PDF] H. Yuling, X. Ruijing, L. Li, J. Xiang, Z. Rui, W. Yujuan, Z. Lijun, D. Chunxian, T. Xinti, X. Wei, et al. EBV-Induced Human CD8+ NKT Cells Suppress Tumorigenesis by EBV-Associated Malignancies Cancer Res., October 15, 2009; 69(20): 7935 - 7944. [Abstract] [Full Text] [PDF] C. Smith, L. Beagley, and R. Khanna Acquisition of Polyfunctionality by Epstein-Barr Virus-Specific CD8+ T Cells Correlates with Increased Resistance to Galectin-1-Mediated Suppression J. Virol., June 15, 2009; 83(12): 6192 - 6198. [Abstract] [Full Text] [PDF] S. J. Rodig, J. Ouyang, P. Juszczynski, T. Currie, K. Law, D. S. Neuberg, G. A. Rabinovich, M. A. Shipp, and J. L. Kutok AP1-Dependent Galectin-1 Expression Delineates Classical Hodgkin and Anaplastic Large Cell Lymphomas from Other Lymphoid Malignancies with Shared Molecular Features Clin. Cancer Res., June 1, 2008; 14(11): 3338 - 3344. [Abstract] [Full Text] [PDF] V. L. J. L. Thijssen, F. Poirier, L. G. Baum, and A. W. Griffioen Galectins in the tumor endothelium: opportunities for combined cancer therapy Blood, October 15, 2007; 110(8): 2819 - 2827. [Abstract] [Full Text] [PDF] P. Juszczynski, J. Ouyang, S. Monti, S. J. Rodig, K. Takeyama, J. Abramson, W. Chen, J. L. Kutok, G. A. Rabinovich, and M. A. Shipp The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma PNAS, August 7, 2007; 104(32): 13134 - 13139. [Abstract] [Full Text] [PDF]

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