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 Blood, 1 September 2007, Vol. 110, No. 5, pp. 1550-1558.
Prepublished online as a Blood First Edition Paper on May 14, 2007; DOI 10.1182/blood-2007-01-069229.

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IMMUNOBIOLOGY

Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function

Jan Kubach1, Petra Lutter2, Tobias Bopp3, Sabine Stoll1, Christian Becker1, Eva Huter1, Christoph Richter3, Petra Weingarten2, Tobias Warger3, Jürgen Knop1, Stefan Müllner2, John Wijdenes4, Hansjörg Schild3, Edgar Schmitt3, and Helmut Jonuleit1

1 Department of Dermatology, Johannes Gutenberg-University, Mainz, Germany; 2 Protagen AG, Dortmund, Germany; 3 Institute of Immunology, Johannes Gutenberg-University, Mainz, Germany; 4 Diaclone SAS, Besancon Cedex, France

CD4+CD25+Foxp3+ regulatory T cells (CD25+ Treg cells) direct the maintenance of immunological self-tolerance by active suppression of autoaggressive T-cell populations. However, the molecules mediating the anergic state and regulatory function of CD25+ Treg cells are still elusive. Using differential proteomics, we identified galectin-10, a member of the lectin family, as constitutively expressed in human CD25+ Treg cells, while they are nearly absent in resting and activated CD4+ T cells. These data were confirmed on the mRNA and protein levels. Single-cell staining and flow cytometry showed a strictly intracellular expression of galectin-10 in CD25+ Treg cells. Specific inhibition of galectin-10 restored the proliferative capacity of CD25+ Treg cells and abrogated their suppressive function. Notably, first identified here as expressed in human T lymphocytes, galectin-10 is essential for the functional properties of CD25+ Treg cells.


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Related Article in Blood Online:

Suppression, surprise: galectin-10 and Treg cells
Helene F. Rosenberg
Blood 2007 110: 1407-1408. [Full Text] [PDF]



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