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Blood, 1 September 2007, Vol. 110, No. 5, pp. 1603-1606. Prepublished online as a Blood First Edition Paper on April 26, 2007; DOI 10.1182/blood-2007-01-066258. This Article Full Text Full Text (PDF) Supplemental Methods, Table, and Figures All Versions of this Article: blood-2007-01-066258v1 110/5/1603    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Solomou, E. E. Articles by Young, N. S. Search for Related Content PubMed PubMed Citation Articles by Solomou, E. E. Articles by Young, N. S. Related Collections Immunobiology Red Cells Free Research Articles Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Brief Report Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia Elena E. Solomou1, Katayoun Rezvani1, Stephan Mielke1, Daniela Malide2, Keyvan Keyvanfar1, Valeria Visconte1, Sachiko Kajigaya1, A. John Barrett1, and Neal S. Young1 1 Hematology Branch and 2 Light Microscopy Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD Regulatory T cells are believed to control the development and progression of autoimmunity by suppressing autoreactive T cells. Decreased numbers of CD4+CD25+ FOXP3+ T cells (Tregs) are associated with impaired immune homeostasis and development of autoimmune diseases. The transcription factors FOXP3 and NFAT1 have key roles in regulatory T-cell development and function. We show that Tregs are decreased at presentation in almost all patients with aplastic anemia; FOXP3 protein and mRNA levels also are significantly lower in patients with aplastic anemia and NFAT1 protein levels are decreased or absent. Transfection of FOXP3-deficient CD4+CD25+ T cells from patients with a plasmid encoding wild-type NFAT1 resulted in increased FOXP3 expression in these cells. By NFAT1 knockdown in CD4+CD25+ T cells, FOXP3 expression was decreased when NFAT1 expression was decreased. Our findings indicate that decreased NFAT1 could explain low FOXP3 expression and diminished Treg frequency in aplastic anemia. Treg defects are now implicated in autoimmune marrow failure. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: V. Visconte, N. Raghavachari, D. Liu, K. Keyvanfar, M. J. Desierto, J. Chen, and N. S. Young Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cells Haematologica, February 1, 2010; 95(2): 214 - 223. [Abstract] [Full Text] [PDF] D. Q. Tran, J. Andersson, D. Hardwick, L. Bebris, G. G. Illei, and E. M. Shevach Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures Blood, May 21, 2009; 113(21): 5125 - 5133. [Abstract] [Full Text] [PDF] U. Oh, G. Blevins, C. Griffith, N. Richert, D. Maric, C. R. Lee, H. McFarland, and S. Jacobson Regulatory T Cells Are Reduced During Anti-CD25 Antibody Treatment of Multiple Sclerosis Arch Neurol, April 1, 2009; 66(4): 471 - 479. [Abstract] [Full Text] [PDF] X. Feng, S. Kajigaya, E. E. Solomou, K. Keyvanfar, X. Xu, N. Raghavachari, P. J. Munson, T. M. Herndon, J. Chen, and N. S. Young Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro Blood, April 1, 2008; 111(7): 3675 - 3683. [Abstract] [Full Text] [PDF] A. Bacigalupo Aplastic Anemia: Pathogenesis and Treatment Hematology, January 1, 2007; 2007(1): 23 - 28. [Abstract] [Full Text] [PDF]

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