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Blood, 1 September 2007, Vol. 110, No. 5, pp. 1681-1688. Prepublished online as a Blood First Edition Paper on May 14, 2007; DOI 10.1182/blood-2006-12-060343. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-12-060343v1 110/5/1681    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Peck, A. J. Articles by Boeckh, M. Search for Related Content PubMed PubMed Citation Articles by Peck, A. J. Articles by Boeckh, M. Related Collections Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection Angela J. Peck1,2, Janet A. Englund1,2, Jane Kuypers3, Katherine A. Guthrie2, Lawrence Corey24, Rhoda Morrow2,3, Robert C. Hackman2,3, Anne Cent3, and Michael Boeckh2,4 1 Department of Pediatrics, Children's Hospital and Regional Medical Center and University of Washington, Seattle; 2 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 3 Department of Laboratory Medicine, and 4 Department of Medicine, University of Washington, Seattle The incidence of respiratory virus infection after hematopoietic cell transplantation (HCT) has probably been underestimated with conventional testing methods in symptomatic patients. This prospective study assessed viral infection episodes by testing weekly respiratory samples collected from HCT recipients, with and without symptoms reported by questionnaire, for 100 days after HCT. Samples were tested by culture and direct fluorescent antibody testing for respiratory syncytial virus (RSV), parainfluenza virus (PIV), and influenza A and B, and by quantitative reverse transcription–polymerase chain reaction for RSV, PIV, influenza A and B, and metapneumovirus (MPV). Of 122 patients, 30 (25%) had 32 infection episodes caused by RSV (5), PIV (17), MPV (6), influenza (3), RSV, or influenza (1). PIV, with a cumulative incidence estimate of 17.9%, was the only virus for which asymptomatic infection was detected. Lower virus copy number in patients with no or one symptom compared with 2 or more symptoms was found for all viruses in all patients (P < .001), with PIV infection having a similar virus-specific comparison (P = .004). Subclinical infection with PIV may help explain why infection-control programs that emphasize symptoms are effective against RSV and influenza but often not against PIV. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: W. G. Nichols, A. J. Peck Campbell, and M. Boeckh Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic Advances Clin. Microbiol. Rev., April 1, 2008; 21(2): 274 - 290. [Abstract] [Full Text] [PDF]

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