SEARCH:   Advanced

Blood, 15 September 2007, Vol. 110, No. 6, pp. 1723-1729. Prepublished online as a Blood First Edition Paper on May 11, 2007; DOI 10.1182/blood-2006-10-053736. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-10-053736v1 110/6/1723    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Varki, A. Search for Related Content PubMed PubMed Citation Articles by Varki, A. Related Collections Hemostasis, Thrombosis, and Vascular Biology Reviews in Translational Hematology Free Research Articles Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW IN TRANSLATIONAL HEMATOLOGY Trousseau's syndrome: multiple definitions and multiple mechanisms Ajit Varki1 1 University of California, San Diego, La Jolla In 1865, Armand Trousseau noted that unexpected or migratory thrombophlebitis could be a forewarning of an occult visceral malignancy. An analysis by Sack and colleagues in 1977 extended the term Trousseau's syndrome to include chronic disseminated intravascular coagulopathy associated with microangiopathy, verrucous endocarditis, and arterial emboli in patients with cancer, often occurring with mucin-positive carcinomas. In recent times the term has been ascribed to various clinical situations, ranging all the way from these classic descriptions to any kind of coagulopathy occurring in the setting of any kind of malignancy. These multiple definitions of Trousseau's syndrome are partly the consequence of multiple pathophysiologic mechanisms that apparently contribute to the hypercoagulability associated with cancer. Even the classic syndrome probably represents a spectrum of disorders, ranging from exaggerated fluid-phased thrombosis dependent on prothrombotic agents such as tissue factor to a platelet- and endotheliumum-based selectin-dependent microangiopathy associated with mucin-producing carcinomas, along with thrombin and fibrin production. Also considered here are recent hypotheses about genetic pathways within tumor cells that might trigger these thrombotic phenomena, and the reasons why therapy with heparins of various kinds remain the preferred treatment, probably because of their salutary actions on several of the proposed pathologic mechanisms. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Milsom, N. Magnus, B. Meehan, K. Al-Nedawi, D. Garnier, and J. Rak Tissue Factor and Cancer Stem Cells: Is There a Linkage? Arterioscler Thromb Vasc Biol, December 1, 2009; 29(12): 2005 - 2014. [Abstract] [Full Text] [PDF] F. Schaffner and W. Ruf Tissue Factor and PAR2 Signaling in the Tumor Microenvironment Arterioscler Thromb Vasc Biol, December 1, 2009; 29(12): 1999 - 2004. [Abstract] [Full Text] [PDF] J. I. Zwicker, H. A. Liebman, D. Neuberg, R. Lacroix, K. A. Bauer, B. C. Furie, and B. Furie Tumor-Derived Tissue Factor-Bearing Microparticles Are Associated With Venous Thromboembolic Events in Malignancy Clin. Cancer Res., November 15, 2009; 15(22): 6830 - 6840. [Abstract] [Full Text] [PDF] A. A. Khorana and G. C. Connolly Assessing Risk of Venous Thromboembolism in the Patient With Cancer J. Clin. Oncol., October 10, 2009; 27(29): 4839 - 4847. [Abstract] [Full Text] [PDF] S. P. Shivakumar, D. R. Anderson, and S. Couban Catheter-Associated Thrombosis in Patients With Malignancy J. Clin. Oncol., October 10, 2009; 27(29): 4858 - 4864. [Abstract] [Full Text] [PDF] C. Boccaccio and P. M. Comoglio Genetic Link Between Cancer and Thrombosis J. Clin. Oncol., October 10, 2009; 27(29): 4827 - 4833. [Abstract] [Full Text] [PDF] G. H. Lyman and A. A. Khorana Cancer, Clots and Consensus: New Understanding of an Old Problem J. Clin. Oncol., October 10, 2009; 27(29): 4821 - 4826. [Full Text] [PDF] N. Starling, S. Rao, D. Cunningham, T. Iveson, M. Nicolson, F. Coxon, G. Middleton, F. Daniel, J. Oates, and A. R. Norman Thromboembolism in Patients With Advanced Gastroesophageal Cancer Treated With Anthracycline, Platinum, and Fluoropyrimidine Combination Chemotherapy: A Report From the UK National Cancer Research Institute Upper Gastrointestinal Clinical Studies Group J. Clin. Oncol., August 10, 2009; 27(23): 3786 - 3793. [Abstract] [Full Text] [PDF] M. Provencal, D. Labbe, R. Veitch, D. Boivin, G.-E. Rivard, H. Sartelet, Y. Robitaille, D. Gingras, and R. Beliveau c-Met activation in medulloblastoma induces tissue factor expression and activity: effects on cell migration Carcinogenesis, July 1, 2009; 30(7): 1089 - 1096. [Abstract] [Full Text] [PDF] B. H. Thiers, R. E. Sahn, and J. P. Callen Cutaneous Manifestations of Internal Malignancy CA Cancer J Clin, March 3, 2009; (2009) caac.20005v1. [Abstract] [Full Text] D. MICKELSON, E. N. MADY, and K. TENG A 43-year-old woman with chest pressure Cleveland Clinic Journal of Medicine, March 1, 2009; 76(3): 191 - 198. [Full Text] [PDF] T. Sousou and A. A. Khorana New Insights Into Cancer-Associated Thrombosis Arterioscler Thromb Vasc Biol, March 1, 2009; 29(3): 316 - 320. [Abstract] [Full Text] [PDF] D. L. Ornstein A Nickel's Worth of Cancer Ann Intern Med, September 2, 2008; 149(5): 350 - 352. [Full Text] [PDF] B. Furie and B. C. Furie Mechanisms of Thrombus Formation N. Engl. J. Med., August 28, 2008; 359(9): 938 - 949. [Full Text] [PDF]

	Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020