Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 September 2007, Vol. 110, No. 6, pp. 1831-1839.
Prepublished online as a Blood First Edition Paper on June 6, 2007; DOI 10.1182/blood-2007-01-069401.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
blood-2007-01-069401v1
110/6/1831    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Signer, R. A. J.
Right arrow Articles by Dorshkind, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Signer, R. A. J.
Right arrow Articles by Dorshkind, K.
Related Collections
Right arrow Hematopoiesis and Stem Cells
Right arrow Neoplasia
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

HEMATOPOIESIS

Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia

Robert A. J. Signer1, Encarnacion Montecino-Rodriguez1, Owen N. Witte2,4, Jami McLaughlin2, and Kenneth Dorshkind1

1 Department of Pathology and Laboratory Medicine and the Hematopoietic Malignancies Program, Jonsson Comprehensive Cancer Center; Departments of2 Microbiology, Immunology and Molecular Genetics and 3 Molecular and Medical Pharmacology, David Geffen School of Medicine; and 4 Howard Hughes Medical Institute, University of California, Los Angeles

Reduced lymphopoiesis during aging contributes to declines in immunity, but little consideration has been given to its effect on the development of hematologic disease. This report demonstrates that age-related defects in lymphopoiesis underlie the myeloid dominance of adult leukemia. Using a murine model of chronic myeloid leukemia, an adult-onset malignancy that arises from transformation of hematopoietic stem cells by the BCR-ABLP210 oncogene, we demonstrate that young bone marrow (BM) cells that were transformed with BCR-ABLP210 initiated both a myeloproliferative disorder (MPD) and B-lymphoid leukemia, whereas BCR-ABLP210–transformed old BM cells recapitulated the human disease by inducing an MPD with rare lymphoid involvement. In addition, the lesser severity of MPDs initiated from old BCR-ABLP210–transduced BM cells revealed unappreciated defects in aged myeloid progenitors. These data demonstrate that aging affects patterns of leukemogenesis and indicate that the effects of senescence on hematopoiesis are more extensive than previously appreciated.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 BloodHome page
E. J. Volanakis, R. T. Williams, and C. J. Sherr
Stage-specific Arf tumor suppression in Notch1-induced T-cell acute lymphoblastic leukemia
Blood, November 12, 2009; 114(20): 4451 - 4459.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
R. A.J. Signer, E. Montecino-Rodriguez, O. N. Witte, and K. Dorshkind
Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf
Genes & Dev., November 15, 2008; 22(22): 3115 - 3120.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020