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Blood, 15 September 2007, Vol. 110, No. 6, pp. 1916-1923. Prepublished online as a Blood First Edition Paper on May 17, 2007; DOI 10.1182/blood-2007-02-062117. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-02-062117v1 110/6/1916    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tatsis, N. Articles by Ertl, H. C. J. Search for Related Content PubMed PubMed Citation Articles by Tatsis, N. Articles by Ertl, H. C. J. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines Nia Tatsis1, Julie C. Fitzgerald1,2, Arturo Reyes-Sandoval1,3, Kimberly C. Harris-McCoy1, Scott E. Hensley1, Dongming Zhou1, Shih-Wen Lin1, Ang Bian1, Zhi Quan Xiang1, Amaya Iparraguirre1, Cesar Lopez-Camacho1,4, E. John Wherry1, and Hildegund C. J. Ertl1 1 Wistar Institute, Philadelphia, PA; 2 Children's Hospital of Philadelphia, PA; 3 Oxford University, United Kingdom; 4 Posgrado en Ciencias Quimicas, Instituto de Quimica–, Instituto de Ciencias de la Universidad de Puebla (ICUAP), Benemérita Universidad Autónoma de Puebla (BUAP), Puebla, Mexico CD8+ T cell-numbers rapidly expand and then contract after exposure to their cognate antigen. Here we show that the sustained frequencies of transgene product-specific CD8+ T cells elicited by replication-defective adenovirus vectors are linked to persistence of low levels of transcriptionally active adenovirus vector genomes at the site of inoculation, in liver, and lymphatic tissues. Continuously produced small amounts of antigen maintain fully active effector CD8+ T cells, while also allowing for their differentiation into central memory cells. The long-term persistence of adenoviral vectors may be highly advantageous for their use as vaccines against pathogens for which T-cell–mediated protection requires both fully activated T cells for immediate control of virus-infected cells and central memory CD8+ T cells that, because of their higher proliferative capacity, may be suited best to eliminate cells infected by pathogens that escaped the initial wave of effector T cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Wang, C. Cheng, S.-Y. Ko, W.-P. Kong, M. Kanekiyo, D. Einfeld, R. M. Schwartz, C. R. King, J. G. D. Gall, and G. J. Nabel Delivery of Human Immunodeficiency Virus Vaccine Vectors to the Intestine Induces Enhanced Mucosal Cellular Immunity J. Virol., July 15, 2009; 83(14): 7166 - 7175. [Abstract] [Full Text] [PDF] N. Tatsis, M. O. Lasaro, S.-W. Lin, Z. Q. Xiang, D. Zhou, L. DiMenna, H. Li, A. Bian, S. Abdulla, Y. Li, et al. Adenovirus Vector-Induced Immune Responses in Nonhuman Primates: Responses to Prime Boost Regimens J. Immunol., May 15, 2009; 182(10): 6587 - 6599. [Abstract] [Full Text] [PDF] Z. Li, M. Zhang, C. Zhou, X. Zhao, N. Iijima, and F. R. Frankel Novel Vaccination Protocol with Two Live Mucosal Vectors Elicits Strong Cell-Mediated Immunity in the Vagina and Protects against Vaginal Virus Challenge J. Immunol., February 15, 2008; 180(4): 2504 - 2513. [Abstract] [Full Text] [PDF]

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