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 Blood, 15 September 2007, Vol. 110, No. 6, pp. 2024-2026.
Prepublished online as a Blood First Edition Paper on June 6, 2007; DOI 10.1182/blood-2007-04-086108.

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IMMUNOBIOLOGY

Brief Report

Rapid generation of a functional NK-cell compartment

Martin Prlic1, Daisuke Kamimura1, and Michael J. Bevan1

1 Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle

Bone marrow transplants are an important therapeutic tool for treating certain types of cancer as well as genetic diseases affecting the hematopoietic system. Until the transferred stem cells differentiate and reconstitute the immune system, recipients are at increased risk from opportunistic infections. We report the rapid generation of a functional natural killer (NK) compartment in lethally irradiated mice that received bone marrow cells from a syngeneic donor by treatment with IL-2/anti–IL-2 antibody complexes. We demonstrate that IL-2 complexes specifically expand the donor but not the host NK population and discuss the implications of this finding in the context of graft-versus-host disease and tumor relapse. Finally, we show that NK cells rapidly generated by IL-2 complexes kill MHC class I–deficient cells effectively in vivo. These data underline the unique therapeutic potential of IL-2 complexes.


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