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 Blood, 1 October 2007, Vol. 110, No. 7, pp. 2268-2275.
Prepublished online as a Blood First Edition Paper on June 27, 2007; DOI 10.1182/blood-2007-05-038950.

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HOW I TREAT

How I treat acute lymphocytic leukemia in adults

Jacob M. Rowe1,2, and Anthony H. Goldstone3

1 Rambam Medical Center, Haifa, Israel; 2 Technion, Israel Institute of Technology, Haifa, Israel; 3 University College London (UCL) Hospitals, London, United Kingdom

The treatment of newly diagnosed acute lymphocytic leukemia (ALL) in adults remains unsatisfactory. Not withstanding the outstanding progress in curing childhood ALL, only approximately one third of adults younger than 60 years can be cured, and the overall published survival curves have not changed significantly during the past 15 years. Recent therapeutic advances in allogeneic transplantation through the conduct of large collaborative studies, better understanding of the relevance of cytogenetics, improved molecular techniques for the detection of minimal residual disease, and clinical research into novel biologic and targeted therapies have all combined to offer potentially a better hope for an improved outcome in this disease. The current approach in 2007 to the management of this disease is presented by way of a discussion of illustrative cases. In this uncommon and difficult disease, well-structured intergroup studies will remain vital for future progress.


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