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Blood, 1 October 2007, Vol. 110, No. 7, pp. 2432-2439. Prepublished online as a Blood First Edition Paper on July 2, 2007; DOI 10.1182/blood-2007-02-069997.
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro1 Unité Mixte de Recherche S 608 (UMR-S 608), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de la Méditerranée, Unité de Formation et de Recherche (UFR) de Pharmacie, Marseille, France; 2 Vascular Research Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; 3 Service de Microscopie Electronique, UFR de Médecine, Université de la Méditerranée, Marseille, France; 4 INSERM, Cyceron, Université de Caen, Caen, France
The regulation of plasmin generation on cell surfaces is of critical importance in the control of vascular homeostasis. Cell-derived microparticles participate in the dissemination of biological activities. However, their capacity to promote plasmin generation has not been documented. In this study, we show that endothelial microparticles (EMPs) from tumor necrosis factor
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