Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 October 2007, Vol. 110, No. 8, pp. 2803-2810.
Prepublished online as a Blood First Edition Paper on June 26, 2007; DOI 10.1182/blood-2006-11-055673.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Figures
Right arrow All Versions of this Article:
blood-2006-11-055673v1
110/8/2803    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chung, B.
Right arrow Articles by Weinberg, K. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chung, B.
Right arrow Articles by Weinberg, K. I.
Related Collections
Right arrow Immunobiology
Right arrow Transplantation
Right arrow Immunotherapy
Right arrow Free Research Articles
Right arrowRelated Article in Blood Online
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

PLENARY PAPER

Prevention of graft-versus-host disease by anti–IL-7R{alpha} antibody

Brile Chung1, Eric P. Dudl2, Dullei Min1, Lora Barsky2, Nancy Smiley2, and Kenneth I. Weinberg1

1 Division of Stem Cell Transplantation, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA; 2 Division of Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, CA

Graft-versus-host disease (GVHD) continues to be a serious complication that limits the success of allogeneic bone marrow transplantation (BMT). Using IL-7–deficient murine models, we have previously shown that IL-7 is necessary for the pathogenesis of GVHD. In the present study, we determined whether GVHD could be prevented by antibody-mediated blockade of IL-7 receptor {alpha} (IL-7R{alpha}) signaling. C57/BL6 (H2Kb) recipient mice were lethally irradiated and underwent cotransplantation with T-cell–depleted (TCD) BM and lymph node (LN) cells from allogeneic BALB/c (H2Kd) donor mice. Following transplantation, the allogeneic BMT recipients were injected weekly with either anti–IL-7R{alpha} antibody (100 µg per mouse per week) or PBS for 4 weeks. Anti–IL-7R{alpha} antibody treatment significantly decreased GVHD-related morbidity and mortality compared with placebo (30% to 80%). IL-7R{alpha} blockade resulted in the reduction of donor CD4+ or CD8+ T cells in the periphery by day 30 after transplantation. Paradoxically, the inhibition of GVHD by anti–IL-7R{alpha} antibody treatment resulted in improved long-term thymic and immune function. Blockade of IL-7R by anti–IL-7R{alpha} antibody resulted in elimination of alloreactive T cells, prevention of GVHD, and improvement of donor T-cell reconstitution.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article in Blood Online:

IL-7: griffinesque role in GVHD
Pavan Reddy
Blood 2007 110: 2788. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 JCOHome page
R. M. Dean, T. Fry, C. Mackall, S. M. Steinberg, F. Hakim, D. Fowler, J. Odom, J. Foley, R. Gress, and M. R. Bishop
Association of Serum Interleukin-7 Levels With the Development of Acute Graft-Versus-Host Disease
J. Clin. Oncol., December 10, 2008; 26(35): 5735 - 5741.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020