Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 October 2007, Vol. 110, No. 8, pp. 2819-2827.
Prepublished online as a Blood First Edition Paper on June 25, 2007; DOI 10.1182/blood-2007-03-077792.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
blood-2007-03-077792v1
110/8/2819    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thijssen, V. L. J. L.
Right arrow Articles by Griffioen, A. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thijssen, V. L. J. L.
Right arrow Articles by Griffioen, A. W.
Related Collections
Right arrow Cell Adhesion and Motility
Right arrow Signal Transduction
Right arrow Hemostasis, Thrombosis, and Vascular Biology
Right arrow Neoplasia
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

REVIEW ARTICLE

Galectins in the tumor endothelium: opportunities for combined cancer therapy

Victor L. J. L. Thijssen1, Françoise Poirier2, Linda G. Baum3, and Arjan W. Griffioen1

1 Angiogenesis Laboratory, Research Institute for Growth and Development (GROW), Department of Pathology, University Maastricht and Academic Hospital Maastricht, the Netherlands; 2 Institute Jacques Monod, Unité Mixte de Recherche, Centre National de la Recherche Scientifique (UMR CNRS) 7592, Paris, France; 3 Department of Pathology and Laboratory Medicine, University of California School of Medicine, Los Angeles, CA

Galectins are emerging as a family of proteins that play an important role in several steps of tumorigenesis. Evidence is accumulating that galectins are expressed by the tumor endothelium, where they contribute to different steps of tumor progression such as immune escape and metastasis. Recent studies have identified an important role for galectins in tumor angiogenesis. Moreover, it has been shown that galectins in the endothelium can be targeted for therapeutic applications. This opens a window of opportunity for the development of tumor-type independent treatment strategies. This review focuses on the expression of galectins in the tumor endothelium, their contribution to tumor progression, and their application in tumor-type independent cancer therapy.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 GlycobiologyHome page
C. Cederfur, E. Salomonsson, J. Nilsson, A. Halim, C. T Oberg, G. Larson, U. J Nilsson, and H. Leffler
Different affinity of galectins for human serum glycoproteins: Galectin-3 binds many protease inhibitors and acute phase proteins
Glycobiology, May 1, 2008; 18(5): 384 - 394.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
V. L. Thijssen, S. Hulsmans, and A. W. Griffioen
The Galectin Profile of the Endothelium: Altered Expression and Localization in Activated and Tumor Endothelial Cells
Am. J. Pathol., February 1, 2008; 172(2): 545 - 553.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
Sponsor: Genentech BioOncology and and Biogen Idec
Blood Online is supported in part by
Genentech BioOncology and Biogen Idec
  Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020