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Blood, 15 October 2007, Vol. 110, No. 8, pp. 2955-2964. Prepublished online as a Blood First Edition Paper on May 31, 2007; DOI 10.1182/blood-2006-10-054726. This Article Full Text Full Text (PDF) Supplemental Methods and Figures All Versions of this Article: blood-2006-10-054726v1 110/8/2955    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sitnicka, E. Articles by Jacobsen, S. E. W. Search for Related Content PubMed PubMed Citation Articles by Sitnicka, E. Articles by Jacobsen, S. E. W. Related Collections Chemokines, Cytokines, and Interleukins Hematopoiesis and Stem Cells Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Critical role of FLT3 ligand in IL-7 receptor–independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors Ewa Sitnicka1, Natalija Buza-Vidas1, Henrik Ahlenius1, Corrado M. Cilio2, Christos Gekas1, Jens M. Nygren1, Robert Månsson1, Min Cheng1, Christina T. Jensen1, Marcus Svensson3, Karin Leandersson4, William W. Agace3, Mikael Sigvardsson1, and Sten Eirik W. Jacobsen1 1 Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund; 2 Department of Clinical Sciences and Department of Paediatrics, Cellular Autoimmunity Unit, Malmö University Hospital, Malmö; 3 Immunology Section, Department of Cell and Molecular Biology, Lund University, Lund; 4 Experimental Pathology, Malmö University Hospital, Malmö, Sweden The molecular pathways regulating lymphoid priming, fate, and development of multipotent bone marrow (BM) stem/progenitor cells that continuously replace thymic progenitors remain largely unknown. Herein, we show that fms-like tyrosine kinase 3 (Flt3) ligand (Fl)–deficient mice have distinct reductions in the earliest thymic progenitors in fetal, postnatal, and adult thymus. A critical role of FL in thymopoiesis was particularly evident in the absence of interleukin-7 receptor (IL-7R) signaling. Fl–/–Il-7r–/– mice have extensive reductions in fetal and postnatal thymic progenitors that result in a loss of active thymopoiesis in adult mice, demonstrating an indispensable role of FL in IL-7R–independent fetal and adult T lymphopoiesis. Moreover, we establish a unique and critical role of FL, distinct from that of IL-7R, in regulation of the earliest lineage-negative (Lin–) Lin–SCA1+KIT+ (LSK) FLT3hi lymphoid-primed multipotent progenitors in BM, demonstrating a key role of FLT3 signaling in regulating the very earliest stages of lymphoid progenitors. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. T. Jensen, C. Boiers, S. Kharazi, A. Lubking, T. Ryden, M. Sigvardsson, E. Sitnicka, and S. E. W. Jacobsen Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development Blood, February 15, 2008; 111(4): 2083 - 2090. [Abstract] [Full Text] [PDF]

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