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 Blood, 15 October 2007, Vol. 110, No. 8, pp. 3078-3081.
Prepublished online as a Blood First Edition Paper on July 6, 2007; DOI 10.1182/blood-2006-12-062984.

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TRANSPLANTATION

Brief Report

G-CSF mobilizes slanDCs (6-sulfo LacNAc+ dendritic cells) with a high proinflammatory capacity

Susanne H. C. Baumeister1, Kristina Hölig2, Martin Bornhäuser2, Michael Meurer3, E. Peter Rieber1, and Knut Schäkel1,3

1 Institute of Immunology, 2 Department of Internal Medicine Medical Faculty, and 3 Department of Dermatology, Technische Universität Dresden, Dresden, Germany

Donor dendritic cells (DCs) play a pivotal role in the induction of immunity and tolerance after peripheral blood stem cell transplantation (PBSCT). Treatment of healthy donors with granulocyte-colony stimulating factor (G-CSF) increases the numbers of tolerogenic DCs and T cells among mobilized blood leukocytes in the graft. SlanDCs (6-sulfo LacNAc+ DCs), a major source of IL-12 and TNF-{alpha} in blood, have not been studied in this respect. Here, we demonstrate that slanDCs (14.9 x 106/L to 64.0 x 106/L) are efficiently mobilized by G-CSF and retain their capacity to produce IL-12 and TNF-{alpha} at high levels. Furthermore, G-CSF–mobilized slanDCs programmed the differentiation of Th1 cells and displayed a particularly strong capacity to stimulate the proliferation of naive allogeneic T cells. Thus, slanDCs transfused into recipients of allogeneic peripheral blood stem cell (PBSC) transplants are functionally fully capable and may be critical in supporting graft-versus-host disease as well as graft-versus-leukemia effects.


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