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Blood, 15 October 2007, Vol. 110, No. 8, pp. 3078-3081. Prepublished online as a Blood First Edition Paper on July 6, 2007; DOI 10.1182/blood-2006-12-062984. This Article Full Text Full Text (PDF) Erratum (v110,p4197) All Versions of this Article: blood-2006-12-062984v1 110/8/3078    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Baumeister, S. H. C. Articles by Schäkel, K. Search for Related Content PubMed PubMed Citation Articles by Baumeister, S. H. C. Articles by Schäkel, K. Related Collections Immunobiology Transplantation Brief Reports Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Brief Report G-CSF mobilizes slanDCs (6-sulfo LacNAc+ dendritic cells) with a high proinflammatory capacity Susanne H. C. Baumeister1, Kristina Hölig2, Martin Bornhäuser2, Michael Meurer3, E. Peter Rieber1, and Knut Schäkel1,3 1 Institute of Immunology, 2 Department of Internal Medicine Medical Faculty, and 3 Department of Dermatology, Technische Universität Dresden, Dresden, Germany Donor dendritic cells (DCs) play a pivotal role in the induction of immunity and tolerance after peripheral blood stem cell transplantation (PBSCT). Treatment of healthy donors with granulocyte-colony stimulating factor (G-CSF) increases the numbers of tolerogenic DCs and T cells among mobilized blood leukocytes in the graft. SlanDCs (6-sulfo LacNAc+ DCs), a major source of IL-12 and TNF- in blood, have not been studied in this respect. Here, we demonstrate that slanDCs (14.9 x 106/L to 64.0 x 106/L) are efficiently mobilized by G-CSF and retain their capacity to produce IL-12 and TNF- at high levels. Furthermore, G-CSF–mobilized slanDCs programmed the differentiation of Th1 cells and displayed a particularly strong capacity to stimulate the proliferation of naive allogeneic T cells. Thus, slanDCs transfused into recipients of allogeneic peripheral blood stem cell (PBSC) transplants are functionally fully capable and may be critical in supporting graft-versus-host disease as well as graft-versus-leukemia effects. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Wehner, D. Wehrum, M. Bornhauser, S. Zhao, K. Schakel, M. P. Bachmann, U. Platzbecker, G. Ehninger, E. P. Rieber, and M. Schmitz Mesenchymal stem cells efficiently inhibit the proinflammatory properties of 6-sulfo LacNAc dendritic cells Haematologica, August 1, 2009; 94(8): 1151 - 1156. [Abstract] [Full Text] [PDF] G.-Y. Chen, K. Sakuma, and R. Kannagi Significance of NF-{kappa}B/GATA Axis in Tumor Necrosis Factor-{alpha}-induced Expression of 6-Sulfated Cell Recognition Glycans in Human T-lymphocytes J. Biol. Chem., December 12, 2008; 283(50): 34563 - 34570. [Abstract] [Full Text] [PDF]

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