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Blood, 1 November 2007, Vol. 110, No. 9, pp. 3122-3127. Prepublished online as a Blood First Edition Paper on July 20, 2007; DOI 10.1182/blood-2006-10-041814. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-10-041814v1 110/9/3122    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Garcia, D. A. Articles by Crowther, M. A. Search for Related Content PubMed PubMed Citation Articles by Garcia, D. A. Articles by Crowther, M. A. Related Collections How I Treat Free Research Articles Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HOW I TREAT How we diagnose and treat thrombotic manifestations of the antiphospholipid syndrome: a case-based review David A. Garcia1, Munther A. Khamashta2, and Mark A. Crowther3 1 Department of Internal Medicine, University of New Mexico, Albuquerque, NM; 2 Lupus Research Unit, The Rayne Institute, King's College London School of Medicine at Guy's, King's, and St Thomas' Hospitals, St Thomas' Hospital, London, United Kingdom; and 3 Department of Medicine, McMaster University, Hamilton, ON Antiphospholipid antibodies including anticardiolipin antibodies, lupus anticoagulants, and anti–ß2 glycoprotein-1–specific antibodies may identify patients at elevated risk of first or recurrent venous or arterial thromboembolism. Traditionally, published case series supplemented by anecdotal experience have formed the basis of management of patients with these autoantibodies. Over the past several years, studies have described the management of patients with key clinical manifestations of antiphospholipid antibodies, including patients with antiphospholipid antibody syndrome. As a result, evidence-based treatment recommendations are possible for selected patients with, or at risk of, thrombosis in the setting of antiphospholipid antibodies. Unfortunately, most patients encountered in clinical practice do not correspond directly with those enrolled in clinical trials. For such patients, treatment recommendations are based on experience, extrapolation, and less rigorous evidence. This article proposes 5 cases typical of those found in clinical practice and provides recommendations for therapy focused on a series of clinical questions. Whenever possible, the recommendations are based on evidence; however, in many cases, insufficient evidence exists, so the recommendation is experiential. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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