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Blood, 1 January 2008, Vol. 111, No. 1, pp. 132-141. Prepublished online as a Blood First Edition Paper on September 17, 2007; DOI 10.1182/blood-2007-06-095398. This Article Full Text Full Text (PDF) Supplemental Figures and Videos All Versions of this Article: blood-2007-06-095398v1 111/1/132    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Le Guyader, D. Articles by Herbomel, P. Search for Related Content PubMed PubMed Citation Articles by Le Guyader, D. Articles by Herbomel, P. Related Collections Hematopoiesis and Stem Cells Immunobiology Phagocytes Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Origins and unconventional behavior of neutrophils in developing zebrafish Dorothée Le Guyader1, Michael J. Redd2, Emma Colucci-Guyon1, Emi Murayama1, Karima Kissa1, Valérie Briolat1, Elodie Mordelet1, Agustin Zapata3, Hiroto Shinomiya4, and Philippe Herbomel1 1 Unité Macrophages et Développement de l'Immunité, Centre National de la Recherche Scientifique-Unité de Recherche Associée 2578, Institut Pasteur, Paris, France; 2 Huntsman Cancer Institute, University of Utah, Salt Lake City; 3 Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain; and 4 Department of Immunology and Host Defenses, Ehime University School of Medicine, Shigenobu, Ehime, Japan The first leukocytes that arise in the development of vertebrate embryos are the primitive macrophages, which differentiate in the yolk sac and then quickly invade embryonic tissues. These macrophages have been considered to constitute a separate lineage, giving rise to no other cell type. Using an in vivo photoactivatable cell tracer in the transparent zebrafish (Danio rerio) embryo, we demonstrated that this lineage also gave rise to an equal or higher number of neutrophilic granulocytes. We were surprised to find that the differentiation of these primitive neutrophils occurs only after primitive myeloid progenitors have dispersed in the tissues. By 2 days after fertilization, these neutrophils have become the major leukocyte type found wandering in the epidermis and mesenchyme. Like the primitive macrophages, all primitive and larval neutrophils express PU.1 and L-plastin and they are highly attracted to local infections, yet only a small fraction of them phagocytose microbes, and to a much lesser extent per cell than the macrophages. They are also attracted to variously stressed or malformed tissues, suggesting a wider role than antimicrobial defense. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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