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Blood, 1 January 2008, Vol. 111, No. 1, pp. 16-24. This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Beutler, E. Search for Related Content PubMed PubMed Citation Articles by Beutler, E. Related Collections ASH 50th Anniversary Reviews Red Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  ASH 50TH ANNIVERSARY REVIEW Glucose-6-phosphate dehydrogenase deficiency: a historical perspective Ernest Beutler1 1 Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA Glucose-6-phosphate dehydrogenase deficiency serves as a prototype of the many human enzyme deficiencies that are now known. Since its discovery more than 50 years ago, the high prevalence of the defect and the easy accessibility of the cells that manifest it have made it a favorite tool of biochemists, epidemiologists, geneticists, and molecular biologists as well as clinicians. In this brief historical review, we trace the discovery of this defect, its clinical manifestations, detection, population genetics, and molecular biology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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