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Blood, 1 January 2008, Vol. 111, No. 1, pp. 50-59. Prepublished online as a Blood First Edition Paper on September 27, 2007; DOI 10.1182/blood-2007-07-099598. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-07-099598v1 111/1/50    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hart, G. Articles by Shachar, I. Search for Related Content PubMed PubMed Citation Articles by Hart, G. Articles by Shachar, I. Related Collections Cell Adhesion and Motility Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES, CYTOKINES, AND INTERLEUKINS IL-15 regulates immature B-cell homing in an Ly49D-, IL-12–, and IL-18–dependent manner Gili Hart1, Tamar Avin-Wittenberg1, and Idit Shachar1 1 Department of Immunology, Weizmann Institute of Science, Rehovot, Israel To complete their maturation and participate in the humoral immune response, immature B cells that leave the bone marrow are targeted to specific areas in the spleen, where they differentiate into mature cells. Previously, we showed that immature B cells actively down-regulate their integrin-mediated migration to lymph nodes or to sites of inflammation, enabling their targeting to the spleen for final maturation. This inhibition is mediated by IFN-, which is transcribed and secreted at low levels by these immature B cells; IFN- expression is extinguished following B-cell maturation. Stimulation of the MHC class I receptor, Ly49D, triggers a signaling cascade that increases transcription of both IL-12 (p40) and IL-18; these, in turn, induce the secretion of IFN-. In the present study, we demonstrate that Ly49D-dependent secretion of IL-12 and IL-18 induces IL-15 expression by immature B cells, and that these 3 factors together regulate IFN- production that inhibits their ability to home to the lymph nodes or to sites of inflammation. Thus, IL-15 controls immature B-cell homing, resulting in shaping the B-cell repertoire to enable an efficient immune response. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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