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Blood, 15 May 2008, Vol. 111, No. 10, pp. 5008-5016. Prepublished online as a Blood First Edition Paper on March 4, 2008; DOI 10.1182/blood-2007-11-122259. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2007-11-122259v1 111/10/5008    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Guia, S. Articles by Vivier, E. Search for Related Content PubMed PubMed Citation Articles by Guia, S. Articles by Vivier, E. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo Sophie Guia13, Céline Cognet14, Ludovic de Beaucoudrey5,6, Marlowe S. Tessmer7, Emmanuelle Jouanguy5,6, Claire Berger8, Orchidée Filipe-Santos5,6, Jacqueline Feinberg5,6, Yildiz Camcioglu9, Jacob Levy10, Suliman Al Jumaah11, Sami Al-Hajjar11, Jean-Louis Stephan8, Claire Fieschi12, Laurent Abel5,6, Laurent Brossay7, Jean-Laurent Casanova5,6,13, and Eric Vivier14 1 Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Marseille, France; 2 Inserm U631, Marseille, France; 3 Centre National de la Recherche Scientifique (CNRS), UMR6102, Marseille, France; 4 Hôpital de la Conception, Assistance Publique–Hôpitaux de Marseille, Marseille, France; 5 Laboratoire de Génétique Humaine des Maladies Infectieuses, Inserm U550, Paris, France; 6 Université Paris René Descartes, Faculté de Médecine Necker, Paris, France; 7 Department of Molecular Microbiology and Immunology, Brown University, Providence, RI; 8 Service de Pédiatrie, Centre Hospitalier Universitaire (CHU), St Etienne, France; 9 Department of Pediatrics, Infectious Diseases, Clinical Immunology and Allergy Division, Cerrahpaçsa Medical School, Istanbul University, Istanbul, Turkey; 10 Pediatric Department, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel; 11 Department of Pediatrics, King Faysal Hospital and Research Center, Riyadh, Saudi Arabia; 12 Service d'Immunopathologie, Hôpital Saint-Louis, Paris, France; and 13 Unité d'Immuno-Hématologie, Hôpital Necker, Paris, France Natural killer (NK) cells have been originally defined by their "naturally occurring" effector function. However, only a fraction of human NK cells is reactive toward a panel of prototypical tumor cell targets in vitro, both for the production of interferon- (IFN-) and for their cytotoxic response. In patients with IL12RB1 mutations that lead to a complete IL-12Rβ1 deficiency, the size of this naturally reactive NK cell subset is diminished, in particular for the IFN- production. Similar data were obtained from a patient with a complete deficit in IL-12p40. In addition, the size of the subset of effector memory T cells expressing CD56 was severely decreased in IL-12Rβ1– and IL-12p40–deficient patients. Human NK cells thus require in vivo priming with IL-12/23 to acquire their full spectrum of functional reactivity, while T cells are dependent upon IL-12/23 signals for the differentiation and/or the maintenance of CD56+ effector memory T cells. The susceptibility of IL-12/23 axis–deficient patients to Mycobacterium and Salmonella infections in combination with the absence of mycobacteriosis or salmonellosis in the rare cases of human NK cell deficiencies point to a role for CD56+ T cells in the control of these infections in humans. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. Lapaque, T. Walzer, S. Meresse, E. Vivier, and J. Trowsdale Interactions between Human NK Cells and Macrophages in Response to Salmonella Infection J. Immunol., April 1, 2009; 182(7): 4339 - 4348. [Abstract] [Full Text] [PDF] D. van de Wetering, R. A. de Paus, J. T. van Dissel, and E. van de Vosse IL-23 modulates CD56+/CD3- NK Cell and CD56+/CD3+ NK-like T Cell function differentially from IL-12 Int. Immunol., February 1, 2009; 21(2): 145 - 153. [Abstract] [Full Text] [PDF]

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