Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 May 2008, Vol. 111, No. 10, pp. 5028-5036.
Prepublished online as a Blood First Edition Paper on January 15, 2008; DOI 10.1182/blood-2007-06-097410.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Figure
Right arrow All Versions of this Article:
blood-2007-06-097410v1
111/10/5028    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sprague, D. L.
Right arrow Articles by Ratliff, T. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sprague, D. L.
Right arrow Articles by Ratliff, T. L.
Related Collections
Right arrow Hemostasis, Thrombosis, and Vascular Biology
Right arrow Immunobiology
Right arrowRelated Articles in Blood Online
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

IMMUNOBIOLOGY

Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles

Daniel L. Sprague13, Bennett D. Elzey4, Scott A. Crist4, Thomas J. Waldschmidt5, Robert J. Jensen1, and Timothy L. Ratliff13,6,7

1 Department of Urology, University of Iowa, Iowa City; 2 Medical Scientist Training Program, University of Iowa, Iowa City; 3 Department of Microbiology, University of Iowa, Iowa City; 4 Department of Comparative Pathobiology, Purdue University, West Lafayette, IN; 5 Department of Pathology, University of Iowa, Iowa City; 6 Interdisciplinary Immunology Program, University of Iowa, Iowa City; and 7 Purdue Cancer Center, Purdue University, West Lafayette, IN

Although mounting evidence indicates that platelets participate in the modulation of both innate and adaptive immunity, the mechanisms by which platelets exert these effects have not been clearly defined. The study reported herein uses a previously documented adoptive transfer model to investigate the ability of platelet-derived membrane vesicles to communicate activation signals to the B-cell compartment. The findings demonstrate for the first time that platelet-derived membrane vesicles are sufficient to deliver CD154 to stimulate antigen-specific IgG production and modulate germinal center formation through cooperation with responses elicited by CD4+ T cells. The data are consistent with the hypothesis that platelets modulate inflammation and adaptive immunity at sites distant from the location of activation and that platelet-derived membrane vesicles are sufficient to mediate the effect.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Articles in Blood Online:

Platelet components associated with acute transfusion reactions: the role of platelet-derived soluble CD40 ligand
Fabrice Cognasse, Jean Marc Payrat, Larry Corash, Jean Claude Osselaer, and Olivier Garraud
Blood 2008 112: 4779-4780. [Full Text] [PDF]

Response: Are PDMVs the biologically active source of CD154 in ATR?
Bennett D. Elzey, Scott A. Crist, Daniel L. Sprague, and Timothy L. Ratliff
Blood 2008 112: 4780-4781. [Full Text] [PDF]

Microvesicles as immune orchestra conductors
Mariusz Z. Ratajczak
Blood 2008 111: 4832-4833. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 haematolHome page
F. Angelot, E. Seilles, S. Biichle, Y. Berda, B. Gaugler, J. Plumas, L. Chaperot, F. Dignat-George, P. Tiberghien, P. Saas, et al.
Endothelial cell-derived microparticles induce plasmacytoid dendritic cell maturation: potential implications in inflammatory diseases
Haematologica, November 1, 2009; 94(11): 1502 - 1512.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H. Yang, S. Lang, Z. Zhai, L. Li, W. H. A. Kahr, P. Chen, J. Brkic, C. M. Spring, M. J. Flick, J. L. Degen, et al.
Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression
Blood, July 9, 2009; 114(2): 425 - 436.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Cognasse, J. M. Payrat, L. Corash, J. C. Osselaer, and O. Garraud
Platelet components associated with acute transfusion reactions: the role of platelet-derived soluble CD40 ligand
Blood, December 1, 2008; 112(12): 4779 - 4780.
[Full Text] [PDF]

Home page
 BloodHome page
B. D. Elzey, S. A. Crist, D. L. Sprague, and T. L. Ratliff
Response: Are PDMVs the biologically active source of CD154 in ATR?
Blood, December 1, 2008; 112(12): 4780 - 4781.
[Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020