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 Blood, 15 May 2008, Vol. 111, No. 10, pp. 5028-5036.
Prepublished online as a Blood First Edition Paper on January 15, 2008; DOI 10.1182/blood-2007-06-097410.

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IMMUNOBIOLOGY

Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles

Daniel L. Sprague13, Bennett D. Elzey4, Scott A. Crist4, Thomas J. Waldschmidt5, Robert J. Jensen1, and Timothy L. Ratliff13,6,7

1 Department of Urology, University of Iowa, Iowa City; 2 Medical Scientist Training Program, University of Iowa, Iowa City; 3 Department of Microbiology, University of Iowa, Iowa City; 4 Department of Comparative Pathobiology, Purdue University, West Lafayette, IN; 5 Department of Pathology, University of Iowa, Iowa City; 6 Interdisciplinary Immunology Program, University of Iowa, Iowa City; and 7 Purdue Cancer Center, Purdue University, West Lafayette, IN

Although mounting evidence indicates that platelets participate in the modulation of both innate and adaptive immunity, the mechanisms by which platelets exert these effects have not been clearly defined. The study reported herein uses a previously documented adoptive transfer model to investigate the ability of platelet-derived membrane vesicles to communicate activation signals to the B-cell compartment. The findings demonstrate for the first time that platelet-derived membrane vesicles are sufficient to deliver CD154 to stimulate antigen-specific IgG production and modulate germinal center formation through cooperation with responses elicited by CD4+ T cells. The data are consistent with the hypothesis that platelets modulate inflammation and adaptive immunity at sites distant from the location of activation and that platelet-derived membrane vesicles are sufficient to mediate the effect.


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Related Article in Blood Online:

Microvesicles as immune orchestra conductors
Mariusz Z. Ratajczak
Blood 2008 111: 4832-4833. [Full Text] [PDF]





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