Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 May 2008, Vol. 111, No. 10, pp. 5182-5186.
Prepublished online as a Blood First Edition Paper on March 13, 2008; DOI 10.1182/blood-2007-10-117705.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Methods
Right arrow All Versions of this Article:
blood-2007-10-117705v1
111/10/5182    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, Y.-Y.
Right arrow Articles by Ptasznik, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, Y.-Y.
Right arrow Articles by Ptasznik, A.
Related Collections
Right arrow Neoplasia
Right arrow Brief Reports
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

NEOPLASIA

Brief Report

BCR-ABL1 alters SDF-1{alpha}–mediated adhesive responses through the β2 integrin LFA-1 in leukemia cells

Ying-Yu Chen1, Mobeen Malik2, Brian E. Tomkowicz1, Ronald G. Collman2, and Andrzej Ptasznik1

1 Divisions of Hematology and Oncology and 2 Pulmonary Allergy and Critical Care, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia

Stromal-derived factor-1 (SDF-1) and its receptor, CXCR4, are essential for normal hematopoietic progenitor cell movement and adherence within the bone marrow microenvironment. In leukemia, the BCR-ABL1 oncoprotein inhibits SDF-1–dependent cell trafficking within the bone marrow through a mechanism that is not fully understood. Here, we report that BCR-ABL1 in malignant cells constitutively increases expression of activation-dependent epitopes of the β2 integrin LFA-1. This is associated with the complete loss of responsiveness of LFA-1 to SDF-1–induced "inside-out" signaling involving CXCR4 and Lyn, leading to aberrant adhesive responses. These data provide a novel, LFA-1–mediated mechanism whereby BCR-ABL1 inhibits SDF-1 action in malignant progenitors.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. Malik, Y.-Y. Chen, M. F. Kienzle, B. E. Tomkowicz, R. G. Collman, and A. Ptasznik
Monocyte Migration and LFA-1-Mediated Attachment to Brain Microvascular Endothelia Is Regulated by SDF-1{alpha} through Lyn Kinase
J. Immunol., October 1, 2008; 181(7): 4632 - 4637.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020