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Blood, 1 June 2008, Vol. 111, No. 11, pp. 5271-5281. This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wagner, D. D. Articles by Frenette, P. S. Search for Related Content PubMed PubMed Citation Articles by Wagner, D. D. Articles by Frenette, P. S. Related Collections Hemostasis, Thrombosis, and Vascular Biology Free Research Articles ASH 50th Anniversary Reviews Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  ASH 50TH ANNIVERSARY REVIEW The vessel wall and its interactions Denisa D. Wagner1, and Paul S. Frenette2 1 Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA; and 2 Department of Medicine, Black Family Stem Cell Institute and Immunology Institute, Mount Sinai Medical School, New York, NY Blood cell interactions with the vessel wall were first documented almost 170 years ago. Modern advances have revealed that leukocyte and platelet interactions with the endothelium are at the nexus of complex, dynamic cellular and molecular networks that, when dysregulated, may lead to pathological inflammation and thrombosis, which are major sources of morbidity and mortality in the Western world. In this review, we relate the history of blood cell interactions with the vasculature, discuss recent progress, and raise some unresolved questions awaiting the field. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. E. Walshe, V. S. Dole, A. S.R. Maharaj, I. S. Patten, D. D. Wagner, and P. A. D'Amore Inhibition of VEGF or TGF-{beta} Signaling Activates Endothelium and Increases Leukocyte Rolling Arterioscler Thromb Vasc Biol, August 1, 2009; 29(8): 1185 - 1192. [Abstract] [Full Text] [PDF] J. Kisucka, A. K. Chauhan, B.-Q. Zhao, I. S. Patten, A. Yesilaltay, M. Krieger, and D. D. Wagner Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis Blood, June 4, 2009; 113(23): 6015 - 6022. [Abstract] [Full Text] [PDF] T. D. Nightingale, K. Pattni, A. N. Hume, M. C. Seabra, and D. F. Cutler Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells Blood, May 14, 2009; 113(20): 5010 - 5018. [Abstract] [Full Text] [PDF] J. Kisucka, A. K. Chauhan, I. S. Patten, A. Yesilaltay, C. Neumann, R. A. Van Etten, M. Krieger, and D. D. Wagner Peroxiredoxin1 Prevents Excessive Endothelial Activation and Early Atherosclerosis Circ. Res., September 12, 2008; 103(6): 598 - 605. [Abstract] [Full Text] [PDF]

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