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Blood, 15 June 2008, Vol. 111, No. 12, pp. 5457-5466. Prepublished online as a Blood First Edition Paper on March 28, 2008; DOI 10.1182/blood-2008-01-136895. This Article Full Text Full Text (PDF) Supplemental Table and Figures All Versions of this Article: blood-2008-01-136895v1 111/12/5457    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sawanobori, Y. Articles by Matsushima, K. Search for Related Content PubMed PubMed Citation Articles by Sawanobori, Y. Articles by Matsushima, K. Related Collections Immunobiology Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES, CYTOKINES, AND INTERLEUKINS Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice Yasushi Sawanobori1,*, Satoshi Ueha1,*, Makoto Kurachi1, Takeshi Shimaoka1, James E. Talmadge2, Jun Abe1, Yusuke Shono1, Masahiro Kitabatake1, Kazuhiro Kakimi3, Naofumi Mukaida4, and Kouji Matsushima1 1 Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 2 Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha; 3 Department of Immunotherapeutics (Medinet), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; and 4 Divisions of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan Tumor growth is associated with aberrant myelopoiesis, including the accumulation of CD11b+Gr-1+ myeloid-derived suppressor cells (MDSCs) that have the potential to promote tumor growth. However, the identity, growth, and migration of tumor-associated MDSCs remain undefined. We demonstrate herein that MDSCs at tumor site were composed primarily of bone marrow-derived CD11b+Gr-1hiLy-6Cint neutrophils and CD11b+Gr-1int/dullLy-6Chi macrophages. Unexpectedly, in vivo bromodeoxyuridine (BrdU) labeling and parabiosis experiments revealed that tumor-infiltrating macrophages were replenished more rapidly than neutrophils. CCR2 deficiency caused striking conversion of infiltrating cellular dominance from macrophages to neutrophils in the tumor with the excessive production of CXCR2 ligands and granulocyte-colony stimulating factor in the tumor without affecting tumor growth. Overall, our data established the identity and dynamics of MDSCs in a tumor-bearing host mediated by chemokines and elucidated unexpected effects of the paucity of macrophages on tumor development. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Toda, Y. Terashima, T. Sato, K. Hirose, S. Kanegasaki, and K. Matsushima FROUNT Is a Common Regulator of CCR2 and CCR5 Signaling to Control Directional Migration J. Immunol., November 15, 2009; 183(10): 6387 - 6394. [Abstract] [Full Text] [PDF] G. Solinas, G. Germano, A. Mantovani, and P. Allavena Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation J. Leukoc. Biol., November 1, 2009; 86(5): 1065 - 1073. [Abstract] [Full Text] [PDF] F. Marttila-Ichihara, K. Auvinen, K. Elima, S. Jalkanen, and M. Salmi Vascular Adhesion Protein-1 Enhances Tumor Growth by Supporting Recruitment of Gr-1+CD11b+ Myeloid Cells into Tumors Cancer Res., October 1, 2009; 69(19): 7875 - 7883. [Abstract] [Full Text] [PDF] T. Baba, Y. Nakamoto, and N. Mukaida Crucial Contribution of Thymic Sirp{alpha}+ Conventional Dendritic Cells to Central Tolerance against Blood-Borne Antigens in a CCR2-Dependent Manner J. Immunol., September 1, 2009; 183(5): 3053 - 3063. [Abstract] [Full Text] [PDF] F. Colotta, P. Allavena, A. Sica, C. Garlanda, and A. Mantovani Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability Carcinogenesis, July 1, 2009; 30(7): 1073 - 1081. [Abstract] [Full Text] [PDF] S. Ostrand-Rosenberg and P. Sinha Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer J. Immunol., April 15, 2009; 182(8): 4499 - 4506. [Abstract] [Full Text] [PDF] H.-J. Ko, J.-M. Lee, Y.-J. Kim, Y.-S. Kim, K.-A Lee, and C.-Y. Kang Immunosuppressive Myeloid-Derived Suppressor Cells Can Be Converted into Immunogenic APCs with the Help of Activated NKT Cells: An Alternative Cell-Based Antitumor Vaccine J. Immunol., February 15, 2009; 182(4): 1818 - 1828. [Abstract] [Full Text] [PDF] J.-I. Youn, S. Nagaraj, M. Collazo, and D. I. Gabrilovich Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice J. Immunol., October 15, 2008; 181(8): 5791 - 5802. [Abstract] [Full Text] [PDF]

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