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Blood, 15 January 2008, Vol. 111, No. 2, pp. 485-491. This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Metcalf, D. Search for Related Content PubMed PubMed Citation Articles by Metcalf, D. Related Collections Hematopoiesis and Stem Cells Signal Transduction ASH 50th Anniversary Reviews Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  ASH 50TH ANNIVERSARY REVIEW Hematopoietic cytokines Donald Metcalf1 1 Walter and Eliza Hall Institute of Medical Research, Victoria, Australia The production of hematopoietic cells is under the tight control of a group of hematopoietic cytokines. Each cytokine has multiple actions mediated by receptors whose cytoplasmic domains contain specialized regions initiating the various responses—survival, proliferation, differentiation commitment, maturation, and functional activation. Individual cytokines can be lineage specific or can regulate cells in multiple lineages, and for some cell types, such as stem cells or megakaryocyte progenitors, the simultaneous action of multiple cytokines is required for proliferative responses. The same cytokines control basal and emergency hematopoietic cell proliferation. Three cytokines, erythropoietin, granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor, have now been in routine clinical use to stimulate cell production and in total have been used in the management of many millions of patients. In this little review, discussion will be restricted to those cytokines well established as influencing the production of hematopoietic cells and will exclude newer candidate regulators and those active on lymphoid cells. As requested, this account will describe the cytokines in a historical manner, using a sequential format of discovery, understanding, validation, and puzzlement, a sequence that reflects the evolving views on these cytokines over the past 50 years. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. R. Hercus, D. Thomas, M. A. Guthridge, P. G. Ekert, J. King-Scott, M. W. Parker, and A. F. Lopez The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease Blood, August 13, 2009; 114(7): 1289 - 1298. [Abstract] [Full Text] [PDF] H. Lei and F. W. Quelle FOXO Transcription Factors Enforce Cell Cycle Checkpoints and Promote Survival of Hematopoietic Cells after DNA Damage Mol. Cancer Res., August 1, 2009; 7(8): 1294 - 1303. [Abstract] [Full Text] [PDF] M. A. Rieger, P. S. Hoppe, B. M. Smejkal, A. C. Eitelhuber, and T. Schroeder Hematopoietic Cytokines Can Instruct Lineage Choice Science, July 10, 2009; 325(5937): 217 - 218. [Abstract] [Full Text] [PDF] A. Y. Lai, A. Watanabe, T. O'Brien, and M. Kondo Pertussis toxin-sensitive G proteins regulate lymphoid lineage specification in multipotent hematopoietic progenitors Blood, June 4, 2009; 113(23): 5757 - 5764. [Abstract] [Full Text] [PDF] D. Nowak, D. Stewart, and H. P. Koeffler Differentiation therapy of leukemia: 3 decades of development Blood, April 16, 2009; 113(16): 3655 - 3665. [Abstract] [Full Text] [PDF] C. Schuster, C. Vaculik, C. Fiala, S. Meindl, O. Brandt, M. Imhof, G. Stingl, W. Eppel, and A. Elbe-Burger HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells J. Exp. Med., January 16, 2009; 206(1): 169 - 181. [Abstract] [Full Text] [PDF] J. E. Dick Stem cell concepts renew cancer research Blood, December 15, 2008; 112(13): 4793 - 4807. [Abstract] [Full Text] [PDF] S. von Vietinghoff and K. Ley Homeostatic Regulation of Blood Neutrophil Counts J. Immunol., October 15, 2008; 181(8): 5183 - 5188. [Abstract] [Full Text] [PDF] H. El Costa, A. Casemayou, M. Aguerre-Girr, M. Rabot, A. Berrebi, O. Parant, M. Clouet-Delannoy, L. Lombardelli, N. Jabrane-Ferrat, D. Rukavina, et al. Critical and Differential Roles of NKp46- and NKp30-Activating Receptors Expressed by Uterine NK Cells in Early Pregnancy J. Immunol., September 1, 2008; 181(5): 3009 - 3017. [Abstract] [Full Text] [PDF]

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