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Blood, 15 January 2008, Vol. 111, No. 2, pp. 715-722. Prepublished online as a Blood First Edition Paper on October 11, 2007; DOI 10.1182/blood-2007-03-079947. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-03-079947v1 111/2/715    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ephrem, A. Articles by Misra, N. Search for Related Content PubMed PubMed Citation Articles by Ephrem, A. Articles by Misra, N. Related Collections Immunobiology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis Amal Ephrem1,4, Souleima Chamat4, Catherine Miquel5, Sylvain Fisson1,3, Luc Mouthon6, Giuseppina Caligiuri1,3, Sandrine Delignat1,3, Sriramulu Elluru1,3, Jagadeesh Bayry1,3, Sebastien Lacroix-Desmazes1,3, José L. Cohen7,8, Benoît L. Salomon7,8, Michel D. Kazatchkine1,3, Srini V. Kaveri1,3, and Namita Misra1,3 1 Centre de Recherche des Cordeliers, Université Pierre et Marie Curie–Paris 6, Unité Mixte de Recherche (UMR) S 872, Paris, France; 2 Université Paris Descartes, UMR S 872, Paris, France; 3 Inserm U872, Paris, France; 4 Laboratory of Applied Immunology, Faculty of Public Health, Lebanese University, Beirut, Lebanon; 5 Inserm U752, University of Paris-5, Hôpital Sainte-Anne, Paris, France; 6 Unité Propre de la Recherche et de l'Enseignement Supérieur Equipe d'Accueil (UPRES-EA) 4058, Paris-Descartes University, Faculty of Medicine, Department of Internal Medicine, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris, France; 7 Université Pierre et Marie Curie–Paris6, UMR 7087, Paris, France; and 8 Centre National de la Recherche Scientifique (CNRS), UMR 7087, Paris, France The clinical use of intravenous immunoglobulin (IVIg) based on its immunomodulatory and anti-inflammatory potential remains an ongoing challenge. Fc receptor-mediated effects of IVIg, although well elucidated in certain pathologies, cannot entirely account for its proven benefit in several autoimmune disorders mediated by autoreactive T cells. In this study, we show that prophylactic infusion of IVIg prevents the development of experimental autoimmune encephalomyelitis (EAE), an accepted animal model for multiple sclerosis (MS). The protection was associated with peripheral increase in CD4+CD25+Foxp3+ regulatory T cell (Treg) numbers and function. The protection was Treg-mediated because IVIg failed to protect against EAE in mice that were depleted of the Treg population. Rather than inducing de novo generation from conventional T cells, IVIg had a direct effect on proliferation of natural Treg. In conclusion, our results highlight a novel mechanism of action of IVIg and provide a rationale to test the use of IVIg as an immunomodulatory tool to enhance Treg in early onset MS and other autoimmune and inflammatory conditions. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Expanding Tregs with IVIg Rachel R. Caspi Blood 2008 111: 481-482. [Full Text] [PDF]

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