|
|
Blood, 15 January 2008, Vol. 111, No. 2, pp. 865-873.
Prepublished online as a Blood First Edition Paper on October 24, 2007; DOI 10.1182/blood-2007-05-092486.
 Previous Article | Table of Contents | Next Article 
NEOPLASIA
Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia
Valter Gattei1,
Pietro Bulian1,
Maria Ilaria Del Principe2,
Antonella Zucchetto1,
Luca Maurillo2,
Francesco Buccisano2,
Riccardo Bomben1,
Michele Dal-Bo1,
Fabrizio Luciano2,
Francesca M. Rossi1,
Massimo Degan1,
Sergio Amadori2, and
Giovanni Del Poeta2
1 Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aviano; and
2 Department of Hematology, S. Eugenio Hospital and University of Tor Vergata, Rome, Italy
CD49d/ 4-integrin is variably expressed in chronic lymphocytic leukemia (CLL). We evaluated its relevance as independent prognosticator for overall survival and time to treatment (TTT) in a series of 303 (232 for TTT) CLLs, in comparison with other biologic or clinical prognosticators (CD38, ZAP-70, immunoglobulin variable heavy chain (IGHV) gene status, cytogenetic abnormalities, soluble CD23, β2-microglobulin, Rai staging). Flow cytometric detection of CD49d was stable and reproducible, and the chosen cut-off (30% CLL cells) easily discriminated CD49dlow from CD49dhigh cases. CD49d, whose expression was strongly associated with that of CD38 (P < .001) and ZAP-70 (P < .001), or with IGHV mutations (P < .001), was independent prognosticator for overall survival along with IGHV mutational status (CD49d hazard ratio, HRCD49d = 3.52, P = .02; HRIGHV = 6.53, P < .001) or, if this parameter was omitted, with ZAP-70 (HRCD49d = 3.72, P = .002; HRZAP-70 = 3.32, P = .009). CD49d was also a prognosticator for TTT (HR = 1.74, P = .007) and refined the impact of all the other factors. Notably, a CD49dhigh phenotype, although not changing the outcome of good prognosis (ZAP-70low, mutated IGHV) CLL, was necessary to correctly prognosticate the shorter TTT of ZAP-70high (HR = 3.12; P = .023) or unmutated IGHV (HR = 2.95; P = .002) cases. These findings support the introduction of CD49d detection in routine prognostic assessment of CLL patients, and suggest both pathogenetic and therapeutic implications for CD49d expression in CLL.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. Visone, L. Z. Rassenti, A. Veronese, C. Taccioli, S. Costinean, B. D. Aguda, S. Volinia, M. Ferracin, J. Palatini, V. Balatti, et al.
Karyotype-specific microRNA signature in chronic lymphocytic leukemia
Blood,
October 29, 2009;
114(18):
3872 - 3879.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Burger, P. Ghia, A. Rosenwald, and F. Caligaris-Cappio
The microenvironment in mature B-cell malignancies: a target for new treatment strategies
Blood,
October 15, 2009;
114(16):
3367 - 3375.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Stamatopoulos, B. Haibe-Kains, C. Equeter, N. Meuleman, A. Soree, C. De Bruyn, D. Hanosset, D. Bron, P. Martiat, and L. Lagneaux
Gene expression profiling reveals differences in microenvironment interaction between patients with chronic lymphocytic leukemia expressing high versus low ZAP70 mRNA
Haematologica,
June 1, 2009;
94(6):
790 - 799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Zucchetto, D. Benedetti, C. Tripodo, R. Bomben, M. Dal Bo, D. Marconi, F. Bossi, D. Lorenzon, M. Degan, F. M. Rossi, et al.
CD38/CD31, the CCL3 and CCL4 Chemokines, and CD49d/Vascular Cell Adhesion Molecule-1 Are Interchained by Sequential Events Sustaining Chronic Lymphocytic Leukemia Cell Survival
Cancer Res.,
May 1, 2009;
69(9):
4001 - 4009.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. N. Hartmann, V. Grabovsky, W. Wang, P. Desch, G. Rubenzer, S. Wollner, I. Binsky, A. Vallon-Eberhard, A. Sapoznikov, M. Burger, et al.
Circulating B-Cell Chronic Lymphocytic Leukemia Cells Display Impaired Migration to Lymph Nodes and Bone Marrow
Cancer Res.,
April 1, 2009;
69(7):
3121 - 3130.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Hernandez, A. E. Rodriguez, M. Gonzalez, R. Benito, C. Fontanillo, V. Sandoval, M. Romero, G. Martin-Nunez, A. G. de Coca, R. Fisac, et al.
A high number of losses in 13q14 chromosome band is associated with a worse outcome and biological differences in patients with B-cell chronic lymphoid leukemia
Haematologica,
March 1, 2009;
94(3):
364 - 371.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. S. Becker, K. J. Kopecky, A. N. Wilks, S. Chien, J. M. Harlan, C. L. Willman, S. H. Petersdorf, D. L. Stirewalt, T. Papayannopoulou, and F. R. Appelbaum
Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia
Blood,
January 22, 2009;
113(4):
866 - 874.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Rossi, A. Zucchetto, F. M. Rossi, D. Capello, M. Cerri, C. Deambrogi, S. Cresta, S. Rasi, L. De Paoli, C. L. Bodoni, et al.
CD49d expression is an independent risk factor of progressive disease in early stage chronic lymphocytic leukemia
Haematologica,
October 1, 2008;
93(10):
1575 - 1579.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. Shanafelt, C. Hanson, G. W. Dewald, T. E. Witzig, B. LaPlant, J. Abrahamzon, D. F. Jelinek, and N. E. Kay
Karyotype Evolution on Fluorescent In Situ Hybridization Analysis Is Associated With Short Survival in Patients With Chronic Lymphocytic Leukemia and Is Related to CD49d Expression
J. Clin. Oncol.,
May 10, 2008;
26(14):
e5 - e6.
[Full Text]
[PDF]
|
|
|
|
|
