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Blood, 1 February 2008, Vol. 111, No. 3, pp. 1282-1286. Prepublished online as a Blood First Edition Paper on November 15, 2007; DOI 10.1182/blood-2007-08-110254. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-08-110254v1 111/3/1282    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pruissen, D. M. O. Articles by Algra, A. Search for Related Content PubMed PubMed Citation Articles by Pruissen, D. M. O. Articles by Algra, A. Related Collections Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Coagulation factor XIII gene variation, oral contraceptives, and risk of ischemic stroke D. Martijn O. Pruissen1, Arjen J. C. Slooter2, Frits R. Rosendaal3,4, Yolanda van der Graaf5, and Ale Algra1,3,5 1 Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht; 2 Department of Intensive Care, University Medical Center Utrecht, Utrecht; 3 Department of Clinical Epidemiology, Leiden University Medical Center, Leiden; 4 Department of Thrombosis and Hemostasis and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden; and 5 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands Prothrombotic conditions are associated with ischemic stroke in young women. In particular, the combination of oral contraceptive use and prothrombotic genetic variants appears to increase the risk of ischemic stroke. We performed a population-based case-control study in 190 women aged 20 to 49 years with ischemic stroke and 767 women without cardiovascular disease stratified for age, calendar year of the index event, and residence. A total of 4 variants of coagulation factor XIII subunit A and B genes (F13A1 and F13B) were investigated. The Phe allele of the F13A1 Tyr204Phe variant was present in 59 (31%) patients and 43 (6%) controls; the odds ratio for ischemic stroke was 9.1 for Phe/Phe and Phe/Tyr versus Tyr/Tyr genotype; the 95% confidence interval was 5.5 to 15. Homozygous genotypes (Phe/Phe) conferred a higher risk (odds ratio, 77; 95% confidence interval, 7.0-848) than heterozygous (Tyr/Phe) genotypes (odds ratio, 8.2; 95% confidence interval, 4.9-14). The risk of ischemic stroke was further increased in carriers of the 204Phe allele using oral contraceptives (odds ratio, 20; 95% confidence interval, 9-46) compared with nonusers with Tyr/Tyr genotype. In conclusion, the F13A1 204Phe allele was strongly associated with ischemic stroke in young women. Oral contraceptive use further increased the risk of ischemic stroke. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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