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Blood, 1 February 2008, Vol. 111, No. 3, pp. 1344-1356. Prepublished online as a Blood First Edition Paper on October 17, 2007; DOI 10.1182/blood-2007-07-101717.
IMMUNOBIOLOGY Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia1 Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY; and 2 Department of Medicine, Division of Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, NY
Hepatitis C virus (HCV) is associated with B-cell lymphoproliferative disorders such as mixed cryoglobulinemia (MC) and B-cell non-Hodgkin lymphoma (B-NHL). The pathogenesis of these disorders remains unclear, and it has been proposed that HCV drives the pro-liferation of B cells. Here we demonstrate that certain HCV+MC+ subjects have clonal expansions of immunoglobulin M (IgM)+
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