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Blood, 1 February 2008, Vol. 111, No. 3, pp. 1560-1566. Prepublished online as a Blood First Edition Paper on October 23, 2007; DOI 10.1182/blood-2007-07-100958. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2007-07-100958v1 111/3/1560    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Le Deley, M.-C. Articles by Brugières, L. Search for Related Content PubMed PubMed Citation Articles by Le Deley, M.-C. Articles by Brugières, L. Related Collections Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Prognostic factors in childhood anaplastic large cell lymphoma: results of a large European intergroup study Marie-Cécile Le Deley1,2, Alfred Reiter3, Denise Williams4, Georges Delsol5,6, Ilske Oschlies7, Keith McCarthy8, Martin Zimmermann9, Laurence Brugières, on behalf of the European Intergroup for Childhood Non-Hodgkin Lymphoma10 1 Biostatistics and Epidemiology Unit, Institut Gustave-Roussy, Villejuif, France; 2 University Paris-Sud, Le Kremlin-Bicêtre, France; 3 Department of Pediatric Hematology and Oncology, Justus Liebig University, Giessen, Germany; 4 Department of Pediatrics, Addenbrookes Hospital, Cambridge; United Kingdom; 5 Inserm, U563, Centre de Physiopathologie de Toulouse Purpan; Université Toulouse III Paul-Sabatier; Toulouse, France; 6 Department of Pathology, Centre Hospitalo-Universitaire Toulouse, Hôpital Purpan, Toulouse, France; 7 Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel, Kiel, Germany; 8 Department of Pathology, Gloucester Hospitals National Health Service Foundation Trust, Gloucester, United Kingdom; 9 Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Hannover, Germany; and 10 Department of Pediatrics, Institut Gustave-Roussy, Villejuif, France To study prognostic factors of progression/relapse, data concerning 225 children enrolled between 1987 and 1997 in Berlin-Frankfurt-Münster, Société Française d'Oncologie Pédiatrique and United Kingdom Children's Cancer Study Group prospective studies for the treatment of anaplastic large cell lymphoma (ALCL) were merged. Median follow-up was 9.3 years. Five-year overall survival and event-free survival of the whole population was 81% (95% confidence interval, 76%-86%) and 69% (63%-74%), respectively. B symptoms, mediastinal involvement, skin lesions, visceral involvement, St Jude stage 3-4, Ann Arbor stage 3-4, and elevated lactate dehydrogenase increased the risk of progression/relapse in the univariate analysis. In the multivariate analysis, 3 factors remained significant: mediastinal involvement (relative risk [RR] = 2.1 [1.2-3.5]), visceral involvement defined as lung, liver, or spleen involvement (RR = 2.1 [1.3-3.6]), and skin lesions (RR = 1.9 [1.1-3.2]). Five-year progression-free survival (PFS) of the 81 patients with none of these risk factors was 89% [82%-96%], contrasting with a 5-year PFS of 61% [53%-69%] in the 144 patients with at least 1 risk factor (RR = 4.4 [2.2-8.9; P < .001). In conclusion, 3 factors associated with an increased risk of failure in childhood ALCL have been defined: mediastinal involvement, visceral involvement, and skin lesions. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Gualco, L. Chioato, L. M. Weiss, W. J. Harrington Jr, and C. E. Bacchi Analysis of Human T-Cell Lymphotropic Virus in CD25+ Anaplastic Large Cell Lymphoma in Children Am J Clin Pathol, July 1, 2009; 132(1): 28 - 33. [Abstract] [Full Text] [PDF] L. Brugieres, M.-C. Le Deley, A. Rosolen, D. Williams, K. Horibe, G. Wrobel, G. Mann, J. Zsiros, A. Uyttebroeck, I. Marky, et al. Impact of the Methotrexate Administration Dose on the Need for Intrathecal Treatment in Children and Adolescents With Anaplastic Large-Cell Lymphoma: Results of a Randomized Trial of the EICNHL Group J. Clin. Oncol., February 20, 2009; 27(6): 897 - 903. [Abstract] [Full Text] [PDF]

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