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 Blood, 1 February 2008, Vol. 111, No. 3, pp. 1735-1738.
Prepublished online as a Blood First Edition Paper on November 5, 2007; DOI 10.1182/blood-2007-02-076000.

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TRANSPLANTATION

Brief Report

Clinical stem-cell sources contain CD8+CD3+ T-cell receptor–negative cells that facilitate bone marrow repopulation with hematopoietic stem cells

Stephanie Bridenbaugh1, Linda Kenins1, Emilie Bouliong-Pillai1, Christian P. Kalberer1, Elena Shklovskaya1, Alois Gratwohl2, and Aleksandra Wodnar-Filipowicz1

1 Experimental Hematology, Department of Research, and 2 Clinical Hematology, University Hospital Basel, Basel, Switzerland

Clinical observations in patients undergoing bone marrow transplantation implicate the involvement of CD8+ cells in promoting the stem-cell engraftment process. These findings are supported by mouse transplant studies, which attributed the engraftment-facilitating function to subpopulations of murine CD8+ cells, but the analogous cells in humans have not been identified. Here, we report that clinical stem-cell grafts contain a population of CD8{alpha}+CD3{epsilon}+ T-cell receptor– negative cells with an engraftment facilitating function, named candidate facilitating cells (cFCs). Purified cFC augmented human hematopoiesis in NOD/SCID mice receiving suboptimal doses of human CD34+ cells. In vitro, cFCs cocultured with CD34+ cells increased hematopoietic colony formation, suggesting a direct effect on clonogenic precursors. These results provide evidence for the existence of rare human CD8+CD3+TCR– cells with engraftment facilitating properties, the adoptive transfer of which could improve the therapeutic outcome of stem-cell transplantation.


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