SEARCH:   Advanced

Blood, 1 February 2008, Vol. 111, No. 3, pp. 1735-1738. Prepublished online as a Blood First Edition Paper on November 5, 2007; DOI 10.1182/blood-2007-02-076000. This Article Full Text Full Text (PDF) Supplemental Table and Figure All Versions of this Article: blood-2007-02-076000v1 111/3/1735    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bridenbaugh, S. Articles by Wodnar-Filipowicz, A. Search for Related Content PubMed PubMed Citation Articles by Bridenbaugh, S. Articles by Wodnar-Filipowicz, A. Related Collections Transplantation Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Brief Report Clinical stem-cell sources contain CD8+CD3+ T-cell receptor–negative cells that facilitate bone marrow repopulation with hematopoietic stem cells Stephanie Bridenbaugh1, Linda Kenins1, Emilie Bouliong-Pillai1, Christian P. Kalberer1, Elena Shklovskaya1, Alois Gratwohl2, and Aleksandra Wodnar-Filipowicz1 1 Experimental Hematology, Department of Research, and 2 Clinical Hematology, University Hospital Basel, Basel, Switzerland Clinical observations in patients undergoing bone marrow transplantation implicate the involvement of CD8+ cells in promoting the stem-cell engraftment process. These findings are supported by mouse transplant studies, which attributed the engraftment-facilitating function to subpopulations of murine CD8+ cells, but the analogous cells in humans have not been identified. Here, we report that clinical stem-cell grafts contain a population of CD8+CD3+ T-cell receptor– negative cells with an engraftment facilitating function, named candidate facilitating cells (cFCs). Purified cFC augmented human hematopoiesis in NOD/SCID mice receiving suboptimal doses of human CD34+ cells. In vitro, cFCs cocultured with CD34+ cells increased hematopoietic colony formation, suggesting a direct effect on clonogenic precursors. These results provide evidence for the existence of rare human CD8+CD3+TCR– cells with engraftment facilitating properties, the adoptive transfer of which could improve the therapeutic outcome of stem-cell transplantation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: U. Langenkamp, U. Siegler, S. Jorger, S. Diermayr, A. Gratwohl, C. P. Kalberer, and A. Wodnar-Filipowicz Human acute myeloid leukemia CD34+CD38- stem cells are susceptible to allorecognition and lysis by single KIR-expressing natural killer cells Haematologica, November 1, 2009; 94(11): 1590 - 1594. [Abstract] [Full Text] [PDF] Y. Huang, I. J. Fugier-Vivier, T. Miller, M. J. Elliott, H. Xu, L. D. Bozulic, P. M. Chilton, and S. T. Ildstad Plasmacytoid Precursor Dendritic Cells From NOD Mice Exhibit Impaired Function: Are They a Component of Diabetes Pathogenesis? Diabetes, September 1, 2008; 57(9): 2360 - 2370. [Abstract] [Full Text] [PDF]

	Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020