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Blood, 1 February 2008, Vol. 111, No. 3, pp. 1735-1738. Prepublished online as a Blood First Edition Paper on November 5, 2007; DOI 10.1182/blood-2007-02-076000.
TRANSPLANTATION Clinical stem-cell sources contain CD8+CD3+ T-cell receptor–negative cells that facilitate bone marrow repopulation with hematopoietic stem cells1 Experimental Hematology, Department of Research, and 2 Clinical Hematology, University Hospital Basel, Basel, Switzerland
Clinical observations in patients undergoing bone marrow transplantation implicate the involvement of CD8+ cells in promoting the stem-cell engraftment process. These findings are supported by mouse transplant studies, which attributed the engraftment-facilitating function to subpopulations of murine CD8+ cells, but the analogous cells in humans have not been identified. Here, we report that clinical stem-cell grafts contain a population of CD8
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