|
|
Blood, 1 February 2008, Vol. 111, No. 3, pp. 981-986.
 Previous Article | Table of Contents | Next Article 
ASH 50TH ANNIVERSARY REVIEW
Historical review: megakaryopoiesis and thrombopoiesis
Kenneth Kaushansky1
1 Department of Medicine, University of California, San Diego
Abstract
The study of thrombopoiesis has evolved greatly since an era when platelets were termed "the dust of the blood," only about 100 years ago. During this time megakaryocytes were identified as the origin of blood platelets; marrow-derived megakaryocytic progenitor cells were functionally defined and then purified; and the primary regulator of the process, thrombopoietin, was cloned and characterized and therapeutic thrombopoietic agents developed. During this journey we continue to learn that the physiologic mechanisms that drive proplatelet formation can be recapitulated in cell-free systems and their biochemistry evaluated; the molecular underpinnings of endomitosis are being increasingly understood; the intracellular signals sent by engagement of a large number of megakaryocyte surface receptors have been defined; and many of the transcription factors that drive megakaryocytic fate determination have been identified and experimentally manipulated. While some of these biologic processes mimic those seen in other cell types, megakaryocytes and platelets possess enough unique developmental features that we are virtually assured that continued study of thrombopoiesis will yield innumerable clinical and scientific insights for many decades to come.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
H. O. Lee, J. M. Davidson, and R. J. Duronio
Endoreplication: polyploidy with purpose
Genes & Dev.,
November 1, 2009;
23(21):
2461 - 2477.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Klimchenko, M. Mori, A. DiStefano, T. Langlois, F. Larbret, Y. Lecluse, O. Feraud, W. Vainchenker, F. Norol, and N. Debili
A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis
Blood,
August 20, 2009;
114(8):
1506 - 1517.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. I. Fortoul, A. Gonzalez-Villalva, G. Pinon-Zarate, V. Rodriguez-Lara, L. F. Montano, and L. Saldivar-Osorio
Ultrastructural megakaryocyte modifications after vanadium inhalation in spleen and bone marrow
J. Electron Microsc. (Tokyo),
June 30, 2009;
(2009)
dfp031v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Soranzo, A. Rendon, C. Gieger, C. I. Jones, N. A. Watkins, S. Menzel, A. Doring, J. Stephens, H. Prokisch, W. Erber, et al.
A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function
Blood,
April 16, 2009;
113(16):
3831 - 3837.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E.-c. Cheng, Q. Luo, E. M. Bruscia, M. J. Renda, J. A. Troy, S. A. Massaro, D. Tuck, V. Schulz, S. M. Mane, N. Berliner, et al.
Role for MKL1 in megakaryocytic maturation
Blood,
March 19, 2009;
113(12):
2826 - 2834.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Diamandis, A. D. Paterson, J. M. Rommens, D. K. Veljkovic, J. Blavignac, D. E. Bulman, J. S. Waye, F. Derome, G. E. Rivard, and C. P. M. Hayward
Quebec platelet disorder is linked to the urokinase plasminogen activator gene (PLAU) and increases expression of the linked allele in megakaryocytes
Blood,
February 12, 2009;
113(7):
1543 - 1546.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Burzynski
New options after first-line therapy for chronic immune thrombocytopenic purpura
Am. J. Health Syst. Pharm.,
January 15, 2009;
66(2_Supplement_2):
S11 - S21.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. O'Brien, S. L. Spinelli, J. Tober, N. Blumberg, C. W. Francis, M. B. Taubman, J. Palis, K. E. Seweryniak, J. M. Gertz, and R. P. Phipps
15-deoxy-{Delta}12,14-PGJ2 enhances platelet production from megakaryocytes
Blood,
November 15, 2008;
112(10):
4051 - 4060.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Cazzola
Molecular basis of thrombocytosis
Haematologica,
May 1, 2008;
93(5):
646 - 648.
[Full Text]
[PDF]
|
|
|
|
|
