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 Blood, 15 February 2008, Vol. 111, No. 4, pp. 2046-2048.
Prepublished online as a Blood First Edition Paper on November 30, 2007; DOI 10.1182/blood-2007-05-092916.

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Brief Report

Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia

Anna G. McDonald1, Katie Yang1, Harold R. Roberts2, Dougald M. Monroe2, and Maureane Hoffman1,3

1 Duke University, Durham, NC; 2 Department of Medicine, University of North Carolina at Chapel Hill; and 3 Pathology and Laboratory Medicine Service, Durham Veterans Affairs Medical Center, Durham, NC

Healing of skin wounds is delayed in hemophilia B (HB) mice. HB mice do not bleed excessively at wounding, yet rebleed hours to days later. Tissue factor (TF) expression is up-regulated by inflammatory cytokines and has been linked to angiogenesis. We hypothesized that impaired thrombin generation in HB leads to impaired TF expression following injury. Punch biopsies were placed on wild-type (WT) and HB mice. Tissues from wound sites were immunostained for TF. Blood vessels are normally surrounded by a coat of pericytes expressing TF. Surprisingly, within a day after wounding TF disappeared from around nearby vessels; returning after 8 days in WT and 10 days in HB mice. The granulation tissue filling the wound during healing also lacked TF around angiogenic vessels. Thus, perivascular TF expression is down-regulated during wound healing. This may prevent thrombosis of neovessels during angiogenesis but renders hemophiliacs vulnerable to hemorrhage during healing.


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