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Blood, 15 February 2008, Vol. 111, No. 4, pp. 2091-2100. Prepublished online as a Blood First Edition Paper on November 14, 2007; DOI 10.1182/blood-2007-07-103200. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-07-103200v1 111/4/2091    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Kenna, T. J. Articles by Steptoe, R. J. PubMed PubMed Citation Articles by Kenna, T. J. Articles by Steptoe, R. J. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses Tony J. Kenna1, Ranjeny Thomas1, and Raymond J. Steptoe1 1 Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Brisbane, Australia Antigen stimulation of naive T cells in conjunction with strong costimulatory signals elicits the generation of effector and memory populations. Such terminal differentiation transforms naive T cells capable of differentiating along several terminal pathways in response to pertinent environmental cues into cells that have lost developmental plasticity and exhibit heightened responsiveness. Because these cells exhibit little or no need for the strong costimulatory signals required for full activation of naive T cells, it is generally considered memory and effector T cells are released from the capacity to be inactivated. Here, we show that steady-state dendritic cells constitutively presenting an endogenously expressed antigen inactivate fully differentiated memory and effector CD8+ T cells in vivo through deletion and inactivation. These findings indicate that fully differentiated effector and memory T cells exhibit a previously unappreciated level of plasticity and provide insight into how memory and effector T-cell populations may be regulated. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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