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 Blood, 15 February 2008, Vol. 111, No. 4, pp. 2158-2162.
Prepublished online as a Blood First Edition Paper on December 12, 2007; DOI 10.1182/blood-2007-10-117309.

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IMMUNOBIOLOGY

Brief Report

Requirement for CD1d expression by B cells to stimulate NKT cell–enhanced antibody production

Gillian A. Lang1, T. Scott Devera1, and Mark L. Lang1

1 Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City

Activation of natural killer-like T (NKT) cells with the CD1d ligand {alpha}-galactosylceramide enhances T-dependent humoral immune responses against coadministered T-dependent Ag. At present, there is little information on the mechanisms involved other than a dependence on CD1d expression by antigen-presenting cells and/or development of the NKT subset. We therefore tested the hypothesis that direct presentation of {alpha}-GC by B cells was required for NKT-enhanced Ab responses against T-dependent Ag. We reconstituted B cell–deficient µMT mice with B cells from C57Bl/6 donors or CD1d–/– donors before immunization with NP-KLH alone or NP-KLH mixed with {alpha}-GC. We made the surprising observation that B-cell expression of CD1d is absolutely required for the NKT-enhanced Ab response. Our data show that the mechanism by which NKT cells enhance humoral immune responses involves interaction with CD1d-expressing B cells.


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 Proc. Natl. Acad. Sci. USAHome page
E. A. Leadbetter, M. Brigl, P. Illarionov, N. Cohen, M. C. Luteran, S. Pillai, G. S. Besra, and M. B. Brenner
NK T cells provide lipid antigen-specific cognate help for B cells
PNAS, June 17, 2008; 105(24): 8339 - 8344.
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