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Blood, 15 February 2008, Vol. 111, No. 4, pp. 2253-2260. Prepublished online as a Blood First Edition Paper on November 27, 2007; DOI 10.1182/blood-2007-07-098848. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-07-098848v1 111/4/2253    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Traverse-Glehen, A. Articles by Felman, P. Search for Related Content PubMed PubMed Citation Articles by Traverse-Glehen, A. Articles by Felman, P. Related Collections Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Splenic red pulp lymphoma with numerous basophilic villous lymphocytes: a distinct clinicopathologic and molecular entity? Alexandra Traverse-Glehen1,2, Lucile Baseggio2,3, Evelyne Callet- Bauchu2,3, Dominique Morel2,3, Sophie Gazzo2,3, Martine Ffrench2,3, Aurélie Verney2, Delphine Rolland2, Catherine Thieblemont2,4, Jean-Pierre Magaud2,3, Gilles Salles2,4, Bertrand Coiffier2,4, Françoise Berger1,2, and Pascale Felman2,3 1 Service d'Anatomie Pathologique Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France; 2 Unité Mixte de Recherche commune au Centre National de Recherche Scientifique (UMR CNRS) 5239 Equipe "Pathologie des Cellules Lymphoides," Université Lyon 1, Lyon, France; 3 Laboratoire d'Hématologie Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France; and 4 Service d'Hématologie Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France The presence of circulating villous lymphocytes (VLs) in lymphoma patients usually points to splenic marginal zone B-cell lymphoma (SMZL), even if the VLs can be found occasionally in other small B-cell lymphomas. However, those cells are variably described, and detailed cytologic characterization is often lacking. We identified lymphoma cases with numerous basophilic VLs among the large group of splenic lymphoma with VLs, and for further delineation, 37 cases with this particular cytology were analyzed. Patients, predominantly older men, presented with moderate lymphocytosis and splenomegaly without pancytopenia. The monoclonal B cells expressed IgM + D, IgM + G, IgM or IgG, as well as CD76 and CD11c, frequently CD103, and rarely CD123. Spleen sections were peculiar, with atrophic white pulp and a monomorphic diffuse lymphoma infiltration in a congested red pulp. Bone marrow infiltration was interstitial and intrasinusoidal without extensive fibrosis. Cytogenetic analysis showed a frequent absence of clonal aberrations (68%). Most cases (79%) were IgH mutated, with an overrepresentation of VH3 and VH4 gene families. These results, as well as the clinical evolution, show that those lymphoma cases represent a homogeneous group distinct from SMZL and reminiscent of hairy cell leukemia variant, perhaps corresponding to a separate lymphoma entity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Y. Dong, J. Weisberger, Z. Liu, and S. Tugulea Immunophenotypic Analysis of CD103+ B-Lymphoproliferative Disorders: Hairy Cell Leukemia and Its Mimics Am J Clin Pathol, April 1, 2009; 131(4): 586 - 595. [Abstract] [Full Text] [PDF]

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