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Blood, 15 February 2008, Vol. 111, No. 4, pp. 2388-2391. Prepublished online as a Blood First Edition Paper on December 12, 2007; DOI 10.1182/blood-2007-09-111245. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-09-111245v1 111/4/2388    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Poncet, D. Articles by Gilson, E. Search for Related Content PubMed PubMed Citation Articles by Poncet, D. Articles by Gilson, E. Related Collections Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief Report Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia Delphine Poncet1,2, Aurélie Belleville1,2, Claire t'Kint de Roodenbeke1, Aude Roborel de Climens1, Elsa Ben Simon1, Hélène Merle-Beral3, Evelyne Callet-Bauchu1,4, Gilles Salles1,4, Laure Sabatier5, Jozo Delic5, and Eric Gilson1,2 1 Laboratoire de Biologie Moleculaire et de Cellule (LBMC), Centre National de la Recherche Scientifique (CNRS) UMR5239, IFR128, Faculté de Médecine Lyon Sud, Université Lyon 1, Lyon; 2 Service de Biologie des Tumeurs, Hôpital Lyon-Sud, Hospices Civils de Lyon, Lyon; 3 Service d'Hématologie Biologique, Groupe Hospitalier Pitié-Salpêtrière, Paris; 4 Service d'Hématologie, Hôpital Lyon-Sud, Hospices Civils de Lyon, Lyon; and 5 Laboratoire d'OncoHématologie, Centre d'Etude Atomique, Institut de Radiobiologie Cellulaire et Moleculaire, Fontenay-aux-Roses, France In this study, we explored the telomeric changes that occur in B-chronic lymphocytic leukemia (B-CLL), in which telomere length has recently been demonstrated to be a powerful prognostic marker. We carried out a transcriptomic analysis of telomerase components (hTERT and DYSKERIN), shelterin proteins (TRF1, TRF2, hRAP1, TIN2, POT1, and TPP1), and a set of multifunctional proteins involved in telomere maintenance (hEST1A, MRE11, RAD50, Ku80, and RPA1) in peripheral B cells from 42 B-CLL patients and 20 healthy donors. We found that, in B-CLL cells, the expressions of hTERT, DYSKERIN, TRF1, hRAP1, POT1, hEST1A, MRE11, RAD50, and KU80 were more than 2-fold reduced (P < .001), contrasting with the higher expression of TPP1 and RPA1 (P < .001). This differential expression pattern suggests that both telomerase down-regulation and changes in telomeric proteins composition are involved in the pathogenesis of B-CLL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Else Telomeres and telomerase in adrenocortical tissue maintenance, carcinogenesis, and aging J. Mol. Endocrinol., October 1, 2009; 43(4): 131 - 141. [Abstract] [Full Text] [PDF]

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