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Blood, 15 March 2008, Vol. 111, No. 6, pp. 3108-3115. Prepublished online as a Blood First Edition Paper on January 10, 2008; DOI 10.1182/blood-2007-08-105965. This Article Full Text Full Text (PDF) Supplemental Table and Figures Additional Supplemental Figures All Versions of this Article: blood-2007-08-105965v1 111/6/3108    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Carlino, C. Articles by Gismondi, A. PubMed PubMed Citation Articles by Carlino, C. Articles by Gismondi, A. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Recruitment of circulating NK cells through decidual tissues: a possible mechanism controlling NK cell accumulation in the uterus during early pregnancy Claudia Carlino1, Helena Stabile1, Stefania Morrone1, Roberta Bulla2, Alessandra Soriani1, Chiara Agostinis2, Fleur Bossi2, Carlo Mocci3, Filippo Sarazani3, Francesco Tedesco2, Angela Santoni1, and Angela Gismondi1 1 Department of Experimental Medicine; and 2 Department of Gynecology, University La Sapienza, Rome, Italy; and 3 Department of Physiology and Pathology, University of Trieste, Trieste, Italy During early pregnancy, uterine mucosa decidualization is accompanied by a drastic enrichment of CD56highCD16– natural killer (NK) cells. Decidual NK (dNK) cells differ from peripheral blood NK (pbNK) cells in several ways, but their origin is still unclear. Our results demonstrate that chemokines present in the uterus can support pbNK cell migration through human endothelial and stromal decidual cells. Notably, we observed that pregnant women's pbNK cells are endowed with higher migratory ability compared with nonpregnant women's or male donors' pbNK cells. Moreover, NK cell migration through decidual stromal cells was increased when progesterone-cultured stromal cells were used as substrate, and this correlated with the ability of progesterone to up-regulate stromal cell chemokine expression. Furthermore, we demonstrate that dNK cells migrate through stromal cells using a distinct pattern of chemokines. Finally, we found that pbNK cells acquire a chemokine receptor pattern similar to that of dNK cells when they contact decidual stromal cells. Collectively these results strongly suggest that pbNK cell recruitment to the uterus contributes to the accumulation of NK cells during early pregnancy; that progesterone plays a crucial role in this event; and that pbNK cells undergo reprogramming of their chemokine receptor profile once exposed to uterine microenvironment. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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