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Blood, 1 April 2008, Vol. 111, No. 7, pp. 3388-3394. Prepublished online as a Blood First Edition Paper on January 31, 2008; DOI 10.1182/blood-2007-10-121285. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2007-10-121285v1 111/7/3388    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Brown, L. M. Articles by Landgren, O. Search for Related Content PubMed PubMed Citation Articles by Brown, L. M. Articles by Landgren, O. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Risk of multiple myeloma and monoclonal gammopathy of undetermined significance among white and black male United States veterans with prior autoimmune, infectious, inflammatory, and allergic disorders Linda Morris Brown1,2, Gloria Gridley1, David Check1, and Ola Landgren1 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD; and 2 RTI International, Rockville, MD In a retrospective cohort of more than 4 million white and black male United States (US) veterans, we explored the role of specific prior autoimmune, infectious, inflammatory, and allergic disorders in the etiology of multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS). Patients were selected from computerized inpatient discharge records at US Veterans Affairs hospitals. The analysis included 4641 patients (3040 white, 1601 black) and 2046 patients (1312 white; 734 black) with a discharge diagnosis of MM and MGUS, respectively. Using Poisson regression, we calculated age-adjusted relative risks (RRs) and 95% confidence intervals (CIs) for the relationship between MM, MGUS, and specific prior medical conditions. Significantly elevated risks of MM were associated with broad categories of autoimmune (RR, 1.15; 95% CI, 1.02-1.28), infectious (RR, 1.29; 95% CI, 1.20-1.38), and inflammatory disorders (RR, 1.18; 95% CI, 1.10-1.27) and specific prior autoimmune (polymyositis/dermatomyositis, systemic sclerosis, autoimmune hemolytic anemia, pernicious anemia, and ankylosing spondylitis), infectious (pneumonia, hepatitis, meningitis, septicemia, herpes zoster, and poliomyelitis), and inflammatory (glomerulonephritis, nephrotic syndrome, and osteoarthritis) disorders. Risks for MGUS were generally of similar magnitude. Our results indicate that various types of immune-mediated conditions might act as triggers for MM/MGUS development. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. P. Bida, R. A. Kyle, T. M. Therneau, L. J. Melton III, M. F. Plevak, D. R. Larson, A. Dispenzieri, J. A. Katzmann, and S. V. Rajkumar Disease Associations With Monoclonal Gammopathy of Undetermined Significance: A Population-Based Study of 17,398 Patients Mayo Clin. Proc., August 1, 2009; 84(8): 685 - 693. [Abstract] [Full Text] [PDF] C. M. Vachon, R. A. Kyle, T. M. Therneau, B. J. Foreman, D. R. Larson, C. L. Colby, T. K. Phelps, A. Dispenzieri, S. K. Kumar, J. A. Katzmann, et al. Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance Blood, July 23, 2009; 114(4): 785 - 790. [Abstract] [Full Text] [PDF] O. Landgren, S. Y. Kristinsson, L. R. Goldin, N. E. Caporaso, C. Blimark, U.-H. Mellqvist, A. Wahlin, M. Bjorkholm, and I. Turesson Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in Sweden Blood, July 23, 2009; 114(4): 791 - 795. [Abstract] [Full Text] [PDF] O. Landgren A role for ionizing radiation in myelomagenesis? Blood, February 19, 2009; 113(8): 1616 - 1617. [Full Text] [PDF] M. Iwanaga, M. Tagawa, K. Tsukasaki, T. Matsuo, K.-i. Yokota, Y. Miyazaki, T. Fukushima, T. Hata, Y. Imaizumi, D. Imanishi, et al. Relationship between monoclonal gammopathy of undetermined significance and radiation exposure in Nagasaki atomic bomb survivors Blood, February 19, 2009; 113(8): 1639 - 1650. [Abstract] [Full Text] [PDF] L. A. Anderson, R. Pfeiffer, J. L. Warren, O. Landgren, S. Gadalla, S. I. Berndt, W. Ricker, R. Parsons, W. Wheeler, and E. A. Engels Hematopoietic Malignancies Associated with Viral and Alcoholic Hepatitis Cancer Epidemiol. Biomarkers Prev., November 1, 2008; 17(11): 3069 - 3075. [Abstract] [Full Text] [PDF]

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