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Blood, 1 April 2008, Vol. 111, No. 7, pp. 3540-3545. Prepublished online as a Blood First Edition Paper on February 1, 2008; DOI 10.1182/blood-2007-11-122945. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-11-122945v1 111/7/3540    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Gallinaro, L. Articles by Casonato, A. PubMed PubMed Citation Articles by Gallinaro, L. Articles by Casonato, A. Related Collections Hemostasis, Thrombosis, and Vascular Biology Transfusion Medicine Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor Lisa Gallinaro1, Maria Grazia Cattini1, Maryta Sztukowska1, Roberto Padrini2, Francesca Sartorello1, Elena Pontara1, Antonella Bertomoro1, Viviana Daidone1, Antonio Pagnan1, and Alessandra Casonato1 1 Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, and 2 Department of Clinical and Experimental Medicine, University of Padua Medical School, Padua, Italy ABO blood groups greatly influence circulating von Willebrand factor (VWF) levels, and O group subjects have lower VWF values. In this study, we investigated whether ABO groups affect VWF survival by monitoring the post-DDAVP (1-desamino-8-d arginine vasopressin) time courses of VWF antigen (VWF:Ag), VWF collagen binding (VWF:CB), and factor VIII (FVIII) in 47 healthy subjects (28 O and 19 non-O blood groups). The elimination half-life (T1/2el) of VWF was found significantly shorter in O than in non-O subjects (10.0 ± 0.8 hours vs 25.5 ± 5.3 hours, respectively; P < .01), as was the T1/2el of VWF:CB (7.9 ± 0.5 hours vs 20.9 ± 4.5 hours; P < .01). A direct linear correlation was found between basal VWF:Ag and T1/2el, subjects with higher VWF levels having longer-surviving VWF. ABO blood groups appeared to strongly influence VWF clearance, but not its synthesis or release from endothelial cells. The VWF propeptide to VWF:Ag ratio, useful for predicting an increased VWF clearance, was found significantly higher in O than in non-O individuals (1.6 ± 0.1 vs 1.2 ± 0.5, P < .001), with values that correlated inversely with T1/2el (P < .001). Based on these findings, we conclude that the lower VWF values in O group individuals is attributable to a shorter VWF survival and circulating VWF values are strongly influenced by its half-life. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Zhang, M. Spreafico, C. Zheng, A. Yang, P. Platzer, M. U. Callaghan, Z. Avci, N. Ozbek, J. Mahlangu, T. Haw, et al. Genotype-phenotype correlation in combined deficiency of factor V and factor VIII Blood, June 15, 2008; 111(12): 5592 - 5600. [Abstract] [Full Text] [PDF]

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