SEARCH:   Advanced

Blood, 1 April 2008, Vol. 111, No. 7, pp. 3579-3590. Prepublished online as a Blood First Edition Paper on January 18, 2008; DOI 10.1182/blood-2007-08-107755. This Article Full Text Full Text (PDF) Supplemental Figure and Videos All Versions of this Article: blood-2007-08-107755v1 111/7/3579    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Nobile, C. Articles by Hivroz, C. PubMed PubMed Citation Articles by Nobile, C. Articles by Hivroz, C. Related Collections Immunobiology Phagocytes Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Cognate CD4+ T-cell–dendritic cell interactions induce migration of immature dendritic cells through dissolution of their podosomes Cinzia Nobile1,2, Marianne Lind1,2, Francesc Miro1,2, Karine Chemin1,2, Marie Tourret1,2, Giovanni Occhipinti3, Stéphanie Dogniaux1,2, Sebastian Amigorena1,2, and Claire Hivroz1,2 1 Institut Curie, Centre de Recherche, Paris, France; 2 Inserm, Unité 653, Immunité et Cancer, Paris, France; and 3 California Institute of Technology, Seismological Laboratory, Pasadena Dendritic cells (DCs) control T cell–based immunity. To do so they need to mature and migrate to sites of T-cell priming. We have previously shown that cognate interactions of human CD4+ T cells with DCs induce DC maturation. We show here that CC chemokines produced during antigen-specific T-DC interactions also induce strong morphologic modifications and migration of immature DCs. These modifications are required for efficient T-cell activation. Moreover, we show that CC chemokines produced during antigen-specific DC–T-cell interactions induce the dissolution of structures involved in cell motility and present on immature DCs (ie, podosomes). We thus propose a model in which chemokines secreted during Ag-specific contact between T cells and DCs induce disassembly of interacting and neighboring immature DC podosomes, leading to recruitment of more immature DCs toward sites of antigenic stimulation and to amplification of T-cell responses. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Blood Online is supported in part by Genentech BioOncology and Biogen Idec
	Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020