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Blood, 15 April 2008, Vol. 111, No. 8, pp. 3968-3977. Prepublished online as a Blood First Edition Paper on February 1, 2008; DOI 10.1182/blood-2007-10-117457. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-10-117457v1 111/8/3968    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Palumbo, A. Articles by Harousseau, J.-L. Search for Related Content PubMed PubMed Citation Articles by Palumbo, A. Articles by Harousseau, J.-L. Related Collections Neoplasia Free Research Articles Review Articles Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW ARTICLE Thalidomide for treatment of multiple myeloma: 10 years later Antonio Palumbo1, Thierry Facon2, Pieter Sonneveld3, Joan Bladè4, Massimo Offidani5, Francesca Gay1, Philippe Moreau6, Anders Waage7, Andrew Spencer8, Heinz Ludwig9, Mario Boccadoro1, and Jean-Luc Harousseau10 1 Division of Hematology, University of Torino, Azienda Ospedaliera S Giovanni Battista, Torino, Italy; 2 University of Lille, Lille, France; 3 Erasmus Medical Center, Rotterdam, The Netherlands; 4 Hematology Department, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; 5 Hematology Clinic, University of Ancona, Ancona, Italy; 6 Hematology Department, University Hospital, Nantes, France; 7 Department of Haematology, University Hospital Trondheim, Trondheim, Norway; 8 Clinical Haematology and BMT, The Alfred Hospital, Melbourne, Australia; 9 First Department of Medicine, Center for Oncology and Haematology, Wilhelminenspital, Vienna, Austria; and 10 Hôspital Hotel-Dieu, Nantes, France Thalidomide, bortezomib, and lenalidomide have recently changed the treatment paradigm of myeloma. In young, newly diagnosed patients, the combination of thalidomide and dexamethasone has been widely used as induction treatment before autologous stem cell transplantation (ASCT). In 2 randomized studies, consolidation or maintenance with low-dose thalidomide has extended both progression-free and overall survival in patients who underwent ASCT at diagnosis. In elderly, newly diagnosed patients, 3 independent randomized studies have reported that the oral combination of melphalan and prednisone plus thalidomide (MPT) is better than the standard melphalan and prednisone (MP). These studies have shown better progression-free survival, and 2 have shown improved overall survival for patients assigned to MPT. In refractory-relapsed disease, combinations including thalidomide with dexamethasone, melphalan, doxorubicin, or cyclophosphamide have been extensively investigated. The risks of side effects are greater when thalidomide is used in combination with other drugs. Thromboembolism and peripheral neuropathy are the major concern. The introduction of anticoagulant prophylaxis has reduced the rate of thromboembolism to less than 10%. Immediate thalidomide dose reduction or discontinuation when paresthesia is complicated by pain or motor deficit has decreased the severity of neuropathy. Future studies will define the most effective or the best sequence of combinations which could improve life expectancy. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Keller, G. Sollberger, and H.-D. Beer Thalidomide Inhibits Activation of Caspase-1 J. Immunol., November 1, 2009; 183(9): 5593 - 5599. [Abstract] [Full Text] [PDF] P. Sonneveld Thalidomide/dexamethasone in myeloma: a double-edged sword Blood, April 9, 2009; 113(15): 3394 - 3394. [Full Text] [PDF] H. Ludwig, R. Hajek, E. Tothova, J. Drach, Z. Adam, B. Labar, M. Egyed, I. Spicka, H. Gisslinger, R. Greil, et al. Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma Blood, April 9, 2009; 113(15): 3435 - 3442. [Abstract] [Full Text] [PDF] H. Brenner, A. Gondos, and D. Pulte Expected long-term survival of patients diagnosed with multiple myeloma in 2006-2010 Haematologica, February 1, 2009; 94(2): 270 - 275. [Abstract] [Full Text] [PDF] D. C. Johnson, S. Corthals, C. Ramos, A. Hoering, K. Cocks, N. J. Dickens, J. Haessler, H. Goldschmidt, J. A. Child, S. E. Bell, et al. Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping Blood, December 15, 2008; 112(13): 4924 - 4934. [Abstract] [Full Text] [PDF] A. Palumbo, S. Bringhen, A. M. Liberati, T. Caravita, A. Falcone, V. Callea, M. Montanaro, R. Ria, A. Capaldi, R. Zambello, et al. Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial Blood, October 15, 2008; 112(8): 3107 - 3114. [Abstract] [Full Text] [PDF] A. A. Argyriou, G. Iconomou, and H. P. Kalofonos Bortezomib-induced peripheral neuropathy in multiple myeloma: a comprehensive review of the literature Blood, September 1, 2008; 112(5): 1593 - 1599. [Abstract] [Full Text] [PDF]

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